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Asian Journal of Biological Sciences
  Year: 2010 | Volume: 3 | Issue: 3 | Page No.: 120-127
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Bioactive Immunomodulatory Fraction from Tridax procumbens

S. Agrawal, S. Khadase and G. Talele

Tridax procumbens (Compositae) have been extensively used in Ayurvedic system of medicine for various ailments. Earlier studies on the extracts of Tridax procumbens revealed remarkable immunomodulatory activity of TPEIF (Tridax procumbens ethanol insoluble fraction) extract. In the present study, the results of the preliminary phytochemical study revealed the presence of alkaloids, phenolics, saponins and tannins in both extract and fractions so, an attempt was made to explore the phytoconstituents responsible for effect on cellular and humoral functions in mice. The in vitro (Phagocytosis) and in vivo (Haemagglutination and Delayed hypersensitivity) were used to study the effect of extract and fractions on the cellular and humoral immunity. Alcoholic extract revealed significant immunostimulation by in vitro phagocytosis, delayed hypersensitivity and haemagglutination model (ANOVA followed by Dunnett’s Multiple Comparison test). Oral administration of EFTP (ethyl acetate fraction) and NFTP (n-butanol fraction) among the four fractions (20-40 mg kg-1) significantly inhibited Sheep Red Blood Cells (SRBC) induced delayed type hypersensitivity reactions and significantly increased the in vitro phagocytic index. It also produced a significant, dose related decrease in sheep erythrocyte specific heamagglutination antibody titre. The results obtained indicate the ability of the flavonoidal fraction (EFTP) and saponin fraction (NFTP) fraction of Tridax procumbens to modulate both cell mediated and the humoral components of the immune system and explored the phytoconstituents responsible for immunomodulatory potential from Tridax procumbens.
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How to cite this article:

S. Agrawal, S. Khadase and G. Talele, 2010. Bioactive Immunomodulatory Fraction from Tridax procumbens. Asian Journal of Biological Sciences, 3: 120-127.





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