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American Journal of Biochemistry and Molecular Biology

Year: 2023 | Volume: 13 | Issue: 1 | Page No.: 11-19
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Authors

Solomon Ochepo Adole

Solomon Ochepo Adole

J.J. Adanu

Keywords

Research Article

Effect of Ethanol Root Extract of Physalis angulata on Kidney Function Biomarkers Following Carbon Tetrachloride (CCl4) Induced Toxicity in Albino Rats

Solomon Ochepo Adole Solomon Ochepo Adole's LiveDNA and J.J. Adanu
Background and Objective: Oxidative stress caused by activities of free radicals has been implicated to play a major role in different disease conditions including organ related diseases such as kidney disease. This study was designed to investigate the effects of Physalis angulata on CCl4 induced oxidative stress. Materials and Methods: The ethanol root extract of Physalis angulata was administered to thirty made albino rats divided into six caged of five rats each. On the 14th day of the experiment, carbon tetrachloride was used to induce oxidative stress in the animal. Samples were collected and assayed for some kidney function biomarkers. Results: The results show that carbon tetrachloride significantly (p<0.05) deteriorated the renal functions of rats. This is seen in the high elevation of renal function biomarkers such as uric acid, urea and creatinine in the positive control group. Lipid peroxidation products such as malondialdehyde (MDA) and lipid hydroperoxides (LHP) was also significantly elevated (p<0.05) in the positive control when compared to the normal control, standard (silymarin) control and all the test groups. The ethanol root extract of Physalis angulata and the standard drug (silymarin) significantly protected the kidney from oxidative stress caused by CCl4. The plant also showed the capacity to stabilize the levels of vitamin C and E following the CCl4 attack. Conclusion: The administration of Physalis angulata root extract showed the potential of quenching or reducing the activities of free radicals thereby reducing oxidative stress.
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