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American Journal of Biochemistry and Molecular Biology
  Year: 2020 | Volume: 10 | Issue: 2 | Page No.: 45-50
DOI: 10.3923/ajbmb.2020.45.50
 
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Levamisole Efficacy on the Helminths of Dog in National Veterinary Research Institute Vom (NVRI) Environment

Ada Gabriel , Yusuf Peter Ofemile and Ameh Matthew Philip

Abstract:
Background and Objectives: Levamisole is an anthelmintics drug principally use for the treatment and control the range of nematodes in animal and human. It is I-isomer of dI-tetramisole with greater safety margin than the racemic mixture tetramisole. This study was designed to examine the efficacy of levamisole by using modified Mc-master technique. Materials and Methods: The experiment was performed on 25 dogs in Vom environment using Modifying Mc-master chamber, polytene bag, concentrated salt solution, microscope, universal bottle and syringe and needle. There were 10 male and 15 female dogs, out of the 25 dogs sampled during the experiment. The organisms identified were Hookworm, Toxocara and Coccidia. The faecal samples were collected directly from both clinical and sub-clinical cases from the rectum labelled and taken to National Veterinary Research institute (NVRI), Vom, Nigeria, Parasitology laboratory for analysis to determine the presence of helminths, eggs and oocyst. The dogs were then treated with levamisole orally and re-sampled after 24 h and analyzed in the NVRI Parasitology laboratory. Results: Out of 25 dogs that were sampled 15 are positive while 10 are negative for helminthosis. The results were obtained by comparing the percentage reduction of worm’s burden of the first sample collected and the second sample collected after medication. The results were expressed in term of percentage reduction, but from the obtained result showed significant reduction between the first and second samples in hookworm, toxocara ova, but there is no significant reduction in coccidia organism. Conclusion: From the study it was reaffirmed that levamisole does not have any effect on the coccidian organism, but it has an anthelmintic property on nematodes such as; hookworms and toxocara organism with some level of resistant in some of the dogs.
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How to cite this article:

Ada Gabriel, Yusuf Peter Ofemile and Ameh Matthew Philip, 2020. Levamisole Efficacy on the Helminths of Dog in National Veterinary Research Institute Vom (NVRI) Environment. American Journal of Biochemistry and Molecular Biology, 10: 45-50.

DOI: 10.3923/ajbmb.2020.45.50

URL: https://scialert.net/abstract/?doi=ajbmb.2020.45.50

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