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American Journal of Biochemistry and Molecular Biology
  Year: 2020 | Volume: 10 | Issue: 1 | Page No.: 12-18
DOI: 10.3923/ajbmb.2020.12.18
 
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Curcumin Confer Radiosensitizing Effect in Breast Cancer Cell Lines via Growth and Motility Inhibition

Nandaki Nag Kanuri, Varalakshmi Mallidi, Jeereddy Sirisha and Y.V. Kanthaiah

Abstract:
Background and Objective: Breast cancer is a major cause of morbidity and mortality in economically developing countries such as India. Evidential research is explained about the anticancer properties. The present study investigated curcumin along with the γ-irradiation effect on two different breast cancer cell lines. Materials and Methods: MDA-MB-231 and MCF-7 cell was irradiated with gamma rays prior to the curcumin treatment. A 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, clonogenic assays and wound healing assays were performed. The results were analyzed with a one-way analysis of variance (ANOVA) with the Bonferroni multiple comparison post-test, using In Stat software version 3.00. Results: The results of the MTT assay showed a statistical significance with p>0.001, similarly, clonogenic assay revealed that the curcumin reduced the proliferation rate of cells. Correspondingly, wound healing assay resulted in control of the cell-cell interaction and cell migration at two different time points. Conclusion: In conclusion, curcumin along with a lower dose (8 Gy) of radiation acted as the best combinatorial drug treatment for breast cancer cell lines. Our findings put up a rationale for further clinical/preclinical analysis of combination treatments with a lower dose and fewer side effects in breast cancer.
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How to cite this article:

Nandaki Nag Kanuri, Varalakshmi Mallidi, Jeereddy Sirisha and Y.V. Kanthaiah, 2020. Curcumin Confer Radiosensitizing Effect in Breast Cancer Cell Lines via Growth and Motility Inhibition. American Journal of Biochemistry and Molecular Biology, 10: 12-18.

DOI: 10.3923/ajbmb.2020.12.18

URL: https://scialert.net/abstract/?doi=ajbmb.2020.12.18

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