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American Journal of Biochemistry and Molecular Biology
  Year: 2014 | Volume: 4 | Issue: 2 | Page No.: 93-98
DOI: 10.3923/ajbmb.2014.93.98
 
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Evaluation of Oxidative Stress and Antioxidant Status in Relation to Glycemic Control in Type 1 and Type 2 Diabetes Mellitus Patients

Syyeda Anees, N. Parveen, Siraj Mohammed and Mohammed Ishaq

Abstract:
Oxidative stress and antioxidant status was evaluated in relation to glycemic control in Type 1 and 2 Diabetes Mellitus patients (DM). A total of 69 DM patients (34 T1 and 35 T2DM cases) were enrolled in the study along with 15 healthy subjects. The patients were grouped into those with good glycemic control and others with poor glycemic control. Serum fructosamine levels were also determined as a supportive parameter for confirming glycemic status. Serum Malondialdehyde (MDA) level was used as a marker of oxidative stress and serum catalase activity was quantitated for an assessment of anti-oxidant status of the patients. Mean MDA levels in poor glycemic control group of T1 and T2DM were significantly higher (p<0.01) not only than the means of the healthy controls but also than the means of diabeteic groups with good glycemic control (p<0.01). Mean serum catalase activity was significantly reduced in DM patients of all the groups compared to that of healthy controls (p<0.05) indicating considerable reduction in the anti-oxidant status of the patients.
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How to cite this article:

Syyeda Anees, N. Parveen, Siraj Mohammed and Mohammed Ishaq, 2014. Evaluation of Oxidative Stress and Antioxidant Status in Relation to Glycemic Control in Type 1 and Type 2 Diabetes Mellitus Patients. American Journal of Biochemistry and Molecular Biology, 4: 93-98.

DOI: 10.3923/ajbmb.2014.93.98

URL: https://scialert.net/abstract/?doi=ajbmb.2014.93.98

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