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American Journal of Biochemistry and Molecular Biology

Year: 2013 | Volume: 3 | Issue: 1 | Page No.: 50-60
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Authors

A.C. Cemaluk Egbuonu

A.C. Cemaluk Egbuonu

L.U.S. Ezeanyika

Keywords

Research Article

L-arginine Exposure Improves Renal Function Markers of Metabolic Syndrome in Female Rats

A.C. Cemaluk Egbuonu A.C. Cemaluk Egbuonu's LiveDNA and L.U.S. Ezeanyika
Female gender is an independent risk factor for the development of metabolic syndrome (MES) (a cluster of features indicating metabolic disorders), that is associated with kidney damage, insulin resistance and a significant reduction in Nitric Oxide (NO), a major metabolite of L-arginine (ARG). This study aimed to ascertain the effect of ARG on selected markers of MES related to kidney damage in female Wistar albino rats. Two groups of rats were given 3 mL kg-1 body weight (b.wt.) of distilled water, DW and 60 mg kg-1 b.wt. of ARG, respectively as control and treated groups. Exposing the female rats to ARG caused a significant decrease (p<0.01) in the concentration of urea (6.34±0.23 mg/100 mL), creatinine (4.41±0.50 mg/100 mL) and albumin (14.30±0.15 mg/100 mL) in rats’ serum. It decreased (p<0.01) creatinine clearance (1.78±0.27 mL min-1) but elicited a significant increase (p<0.01) in the albumin:creatinine ratio (3.27±0.32) of the rats. Improved kidney histology as indicated by lots of renal corpuscles, was observed in the ARG-fed group while correlation analysis showed that urea correlated positively (r = 0.01) with creatinine, albumin and creatinine clearance, but negatively (r = 0.01) with Albumin: Creatinine ratio. The study suggests that L-arginine ingestion could improve these renal function markers and perhaps, metabolic syndrome related to kidney dysfunction, in female Wistar rats. The effect could be concerted and significant as indicated by the histomorpholgy and correlation results. Thus, with the abundance of ARG in nuts, including walnut, cashew nut, ground nut and even coconut, the implication of this study in the prevention and management of MES in, especially female, animals is noteworthy hence, deserve follow up, probably in humans.
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