Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
American Journal of Biochemistry and Molecular Biology
  Year: 2013 | Volume: 3 | Issue: 3 | Page No.: 314-321
DOI: 10.3923/ajbmb.2013.314.321
Modulating Role of Bitter Leaf on Spermatogenic and Steroidogenesis Functions of the Rat Testis
L.C. Saalu, G.G. Akunna and J.O. Ajayi

Abstract:
The characteristic bitter taste of Vernonia amygdalina has been attributed to its anti-nutritional contents such as alkaloids, saponins, tannins and glycosides. Recently the spermiographic effect of the plant in male rats has been reported. The present study examined the effect of bitter leaf extract on 30 days oral administration of 50, 100, 200 mg kg-1 and 60 days oral administration of 200 mg kg-1 b.wt. of the extract on some fertility indices in male wistar rats. At 30 days administration, the extract produced a significant and dose dependent increase (p<0.05) in sperm concentration, percentage motility, morphology and percentage live sperm. There was a decrease in the blood level of Follicle Stimulating Hormone (FSH) but no significant increase in the levels of Leutinizing Hormone (LH) and Testosterone. Administrations of bitter leaf extract at higher dosage (200 mg kg-1 b.wt.) and duration provoked varying degrees of testicular degeneration ranging from a significant reduction in sperm concentration, motility, percentage normal morphology, percentage number of live sperm to a significant increase in the number of percentage abnormal sperm. Evidences suggest that higher dosage of bitter leaf (Vernonia amygdalina) extract administered for a longer duration could be deleterious to the testes.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Nigerian Folklore Medicinal Plants with Potential Antifertility Activity in Males: A Scientific Appraisal
How to cite this article:

L.C. Saalu, G.G. Akunna and J.O. Ajayi, 2013. Modulating Role of Bitter Leaf on Spermatogenic and Steroidogenesis Functions of the Rat Testis. American Journal of Biochemistry and Molecular Biology, 3: 314-321.

DOI: 10.3923/ajbmb.2013.314.321

URL: https://scialert.net/abstract/?doi=ajbmb.2013.314.321

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 

       

       

Curve Bottom