The characteristic bitter taste of Vernonia amygdalina has been attributed
to its anti-nutritional contents such as alkaloids, saponins, tannins and glycosides.
Recently the spermiographic effect of the plant in male rats has been reported.
The present study examined the effect of bitter leaf extract on 30 days oral
administration of 50, 100, 200 mg kg-1 and 60 days oral administration
of 200 mg kg-1 b.wt. of the extract on some fertility indices in
male wistar rats. At 30 days administration, the extract produced a significant
and dose dependent increase (p<0.05) in sperm concentration, percentage motility,
morphology and percentage live sperm. There was a decrease in the blood level
of Follicle Stimulating Hormone (FSH) but no significant increase in the levels
of Leutinizing Hormone (LH) and Testosterone. Administrations of bitter leaf
extract at higher dosage (200 mg kg-1 b.wt.) and duration provoked
varying degrees of testicular degeneration ranging from a significant reduction
in sperm concentration, motility, percentage normal morphology, percentage number
of live sperm to a significant increase in the number of percentage abnormal
sperm. Evidences suggest that higher dosage of bitter leaf (Vernonia amygdalina)
extract administered for a longer duration could be deleterious to the testes. PDFFulltextXMLReferencesCitation
How to cite this article
L.C. Saalu, G.G. Akunna and J.O. Ajayi, 2013. Modulating Role of Bitter Leaf on Spermatogenic and Steroidogenesis Functions of the Rat Testis. American Journal of Biochemistry and Molecular Biology, 3: 314-321.