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American Journal of Biochemistry and Molecular Biology
  Year: 2013 | Volume: 3 | Issue: 1 | Page No.: 159-166
DOI: 10.3923/ajbmb.2013.159.166
 
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Tetranucleotide Repeat Polymorphism in the 3' UTR of the Human Leptin Gene and Risk of Type 2 Diabetes Mellitus in a South Indian Population
Kamakshi Chaithri Ponnaluri, Parimala Narne, Mohd. Siraj and Mohd. Ishaq

Abstract:
Type 2 Diabetes Mellitus (T2DM), an increasingly common serious metabolic disorder has obesity as one of its major predisposing factors. Accumulating evidence suggests that the adipocyte-derived multifunctional hormone, leptin, may play a vital role in the modulation of obesity and subsequent T2DM. The association of polymorphic tetranucleotide repeat (TTTC)n polymorphism in the 3' UTR of the human Leptin gene (LEP-tet) with T2DM was examined in the present study. The study population comprised of 481 subjects including 305 patients and 176 controls. Genotyping of the polymorphic variant was carried out by PCR followed by agarose gel electrophoresis. The alleles of the polymorphism consisted of two groups with different size distributions: the shorter group (class I) and the longer group (class II). Analysis of allele frequencies and genotype frequencies between T2DM subjects and healthy controls revealed no significant differences. Risk estimates for different combinations of the LEP-tet genotypes showed that the I/II genotype was associated with modest 1.46 fold increased risk of T2DM (p = 0.04; 95% CI = 1.01-2.12). A similar trend could not be observed after stratification of the subjects based on sex or obesity. The results obtained in the present study indicated an insignificant influence of the leptin tetranucleotide repeat polymorphism on the development of T2DM. Further studies on a similar aspect would help clarify the issue.
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How to cite this article:

Kamakshi Chaithri Ponnaluri, Parimala Narne, Mohd. Siraj and Mohd. Ishaq, 2013. Tetranucleotide Repeat Polymorphism in the 3' UTR of the Human Leptin Gene and Risk of Type 2 Diabetes Mellitus in a South Indian Population. American Journal of Biochemistry and Molecular Biology, 3: 159-166.

DOI: 10.3923/ajbmb.2013.159.166

URL: https://scialert.net/abstract/?doi=ajbmb.2013.159.166

 
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