Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
American Journal of Biochemistry and Molecular Biology
  Year: 2012 | Volume: 2 | Issue: 4 | Page No.: 227-234
DOI: 10.3923/ajbmb.2012.227.234
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Effect of Oral Exposure to Nitrocellulose Thinner on Haematological Profiles of Male Albino Wistar Rats

Friday E. Uboh, Itoro F. Usoh, Promise Nwankpa and Godwin O. Obochi

Abstract:
Haematological profiles provide important information about the internal environment of a given organism. In this present study, varying concentrations (10, 15, 20 and 25 mg kg-1) of nitrocellulose thinner were orally administered to male albino rats, as single daily dosage for 30 days, to assess the haematological changes associated with oral exposure to solvent. The results showed a significant (p<0.05) dose-dependent decrease in Red Blood Cells (RBC) count, haemoglobin (Hb), Packed Cell Volume (PCV), Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH), Mean Corpuscular Haemoglobin Concentration (MCHC), neutrophils and increase in total White Blood Cells (WBC), platelets and lymphocytes, compared to the control. However, there was no significant (p>0.05) difference in the changes in the level of these parameters in rats exposed to 10 mg kg-1 when compared to the rats exposed to 15 mg kg-1 and 20 mg kg-1 when compared to the rats exposed to 25 mg kg-1 of the solvent. The results recorded in this present study suggested that exposure to nitrocellulose thinner’s constituents, or their metabolites, may be a risk factor for haematotoxicity in mammals. Hence, the haematotoxic properties of nitrocellulose thinner are reported in the study.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Plasma Concentration of Platelet Factor 4: As an Evidence of Platelet Activation in Parasitic Infections
  •    Gongronema latifolium Crude Leaf Extract Reverses Alterations in Haematological Indices and Weight-loss in Diabetic Rats
  •    Phytochemistry and Heamatological Potential of Ethanol Seed Leaf and Pulp Extracts of Carica papaya (Linn.)
  •    Comparative Study of Some Haematological Parameters in Rats Following Ingestion of Crude Oil (Nigerian Bonny Light), Petrol, Kerosene and Diesel
  •    Hematologic and Hepatic Enzyme Alterations Associated with Acute Administration of Antiretroviral Drugs
How to cite this article:

Friday E. Uboh, Itoro F. Usoh, Promise Nwankpa and Godwin O. Obochi, 2012. Effect of Oral Exposure to Nitrocellulose Thinner on Haematological Profiles of Male Albino Wistar Rats. American Journal of Biochemistry and Molecular Biology, 2: 227-234.

DOI: 10.3923/ajbmb.2012.227.234

URL: https://scialert.net/abstract/?doi=ajbmb.2012.227.234

COMMENTS
01 April, 2019
muhammed:
thanks
the research was perfect
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 

Curve Bottom