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American Journal of Biochemistry and Molecular Biology
  Year: 2011 | Volume: 1 | Issue: 1 | Page No.: 82-88
DOI: 10.3923/ajbmb.2011.82.88
 
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Antioxidants and Electrolyte Profile in Early Pregnancy: In vivo Studies

O.I. Iribhogbe, U. Akpamu, J.E. Emordi, A. Aigbiremolen, E.O. Nwoke and B. Idinoje

Abstract:
The effect on electrolyte profile following oral administration of antioxidants (vitamin A, C and E supplements in early pregnancy was investigated using albino rats of the Wistar strain. Eighty-five female rats weighing between 255-300 g were used for the study. They were randomly assigned to three study groups having 5 sub groups with five animals each, a control and vehicle group with five animals each. After pregnancy has been confirmed, the control group was administered 1 mL of distilled water, vehicle group 1 mL of tween 80, while test groups 1, II and III received different doses of vitamin A, C and E, respectively via the intragastric route for 11 days. The administration of vitamin A, C and E in early pregnancy for 11 days produced insignificant changes in serum Na+ levels (p>0.05) and a significant increase in serum Ca2+ level. With the exception of vitamin C, vitamin A and E produce a significant increase in serum K+ and Cl¯ levels. Conclusively administration of vitamin A, C and E in early pregnancy cause no significant alteration in serum Na+ levels. However, care must be taken when vitamin A and E are administered with agents that elevate serum Ca2+ and K+ levels as this may pontentiate hypercalcemia and hyperkalemia, respectively in early pregnancy.
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How to cite this article:

O.I. Iribhogbe, U. Akpamu, J.E. Emordi, A. Aigbiremolen, E.O. Nwoke and B. Idinoje, 2011. Antioxidants and Electrolyte Profile in Early Pregnancy: In vivo Studies. American Journal of Biochemistry and Molecular Biology, 1: 82-88.

DOI: 10.3923/ajbmb.2011.82.88

URL: https://scialert.net/abstract/?doi=ajbmb.2011.82.88

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