Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
American Journal of Biochemistry and Molecular Biology
  Year: 2011 | Volume: 1 | Issue: 3 | Page No.: 237-243
DOI: 10.3923/ajbmb.2011.237.243
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
Evaluation of Toxicological and Standardization Parameters and Phytochemical Investigation of Ficus deltoidea Leaves
Armaghan Shafaei, Elham Farsi, B.M. Khadeer Ahamed, M.J. Ahmad Siddiqui, Idress Hamad Attitalla, I. Zhari and Mohd Z. Asmawi

Abstract:
Medicinal herbs were the primary health care agent over the many centuries before development of modern medicine. The fact that herbal medicines have been employed for such a long time does not guarantee their efficacy and safety. On that basis, an attempt was made on efficacy and safety studies of a well known medicinal herb in Malaysia, Ficus deltoidea by evaluation of toxicological parameter like heavy metals and standardization parameters like, physical constants, ash content, Microbial Limit Test (MLT) and screening phytoconstituents are present in the leaves of F. deltoidea. Heavy metals analysis was done by atomic absorption spectrometry. Physicochemical determinations, including moisture, volatile and total ash content were carried out by Thermogravimetric Analyzer. Microbial Limit Test was done as per the United State Pharmacopoeia method. Thin layer chromatography was carried out for phytochemical screening with normal silica plate using various chemical reagents. The contents of Cd, Pb and As were found to be 0.069, 0.761 and 0.422 ppm, respectively. While Hg was not detected in F. deltoidea leaves. MLT test showed 5.0x106 and 3.3x107 cfu g-1 for Total aerobic microbial count and total combined mold and yeast respectively. However, Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella sp. and Escherichia coli were found to absent. Phytochemical studies of petroleum ether, chloroform, methanol and water extracts showed presence of saponin, amino acid, flavonoids and terpenoids. Hence, there is an urgent need for mandatory evaluation of these parameters in every crude drug before further processing to ensure safety and efficacy of medicinal plants. In conclusion, it was shown that the extracts of F. deltoidea leaves were enriched with chemically diversified phytoconstituents which could be useful for various pharmacological activities.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Hepatoprotective and Healthy Kidney Promoting Potentials of Methanol Extract of Nauclea latifolia in Alloxan Induced Diabetic Male Wistar Albino Rats
  •    Modulation of Blood Glucose Concentration, Lipid Profile and Haematological Parameters in Alloxan Induced Diabetic Rats Using Methanol Extract of Nauclea latifolia Root Bark
  •    Safety and Standardization Indices on Selected Anti-malarial Herbs: Effect on Haematology and Serum Enzyme Levels
  •    Pharmacological Characterization and Beneficial Uses of Punica granatum
How to cite this article:

Armaghan Shafaei, Elham Farsi, B.M. Khadeer Ahamed, M.J. Ahmad Siddiqui, Idress Hamad Attitalla, I. Zhari and Mohd Z. Asmawi, 2011. Evaluation of Toxicological and Standardization Parameters and Phytochemical Investigation of Ficus deltoidea Leaves. American Journal of Biochemistry and Molecular Biology, 1: 237-243.

DOI: 10.3923/ajbmb.2011.237.243

URL: https://scialert.net/abstract/?doi=ajbmb.2011.237.243

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 

       

       

Curve Bottom