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American Journal of Biochemistry and Molecular Biology
  Year: 2011 | Volume: 1 | Issue: 1 | Page No.: 101-105
DOI: 10.3923/ajbmb.2011.101.105
Effect of Polytrin C (Combination Pesticide) on the Ach Ease Inhibition in Plasma and Brain of Wistar Rats
Sekar Babu Hari Ram, Ch. Uma Devi, Ch. Susma, Venkateswara Rao Jasti, T.M. Vijaya Kumar and G. Thirumurugan

Abstract:
The present study has been aimed to screen the sub acute toxicity of a combination pesticide polytrin C which contains an organophosphate and a pyrethroid. First combination pesticide acute studies were carried out in Wistar rats to fix up to LD50 dosage. Polytrin-C show a lesser toxicity when compare to the earlier literature available regarding the toxicity of its constituents profenofos and cypermethrin. Plasma AChE showed a prominent decrease in the both male and female rats of group 4 (34 mg kg-1 b.wt.) while a dose dependent decrease of blood AChE was observed only in female rats, the males showing a decrease only in the highest dose group (34 mg kg-1 b.wt.). In brain, a dose dependent decrease of AChE activity was observed in both male and female rats treated with the pesticide at the doses of 17 and 34 mg kg-1 b.wt. (G3, G4) while the lowest dose group of 8.5 mg kg-1 b.wt. remained on par with the untreated control. The study also revealed that the combination pesticides behave differently and exhibit a different toxicological profile when compared with the toxicity of the individual pesticides in the combination.
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How to cite this article:

Sekar Babu Hari Ram, Ch. Uma Devi, Ch. Susma, Venkateswara Rao Jasti, T.M. Vijaya Kumar and G. Thirumurugan, 2011. Effect of Polytrin C (Combination Pesticide) on the Ach Ease Inhibition in Plasma and Brain of Wistar Rats. American Journal of Biochemistry and Molecular Biology, 1: 101-105.

DOI: 10.3923/ajbmb.2011.101.105

URL: https://scialert.net/abstract/?doi=ajbmb.2011.101.105

 
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