• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. Asian Journal of Biotechnology
  2. Vol 12 (2), 2020
  3. 108-119
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

Asian Journal of Biotechnology

Year: 2020 | Volume: 12 | Issue: 2 | Page No.: 108-119
DOI: 10.3923/ajbkr.2020.108.119

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 1245

Search


Authors


Daniel H.  Mhya

Daniel H. Mhya

LiveDNA: 234.16428

Janet O. Alegbejo

Country: Nigeria

Stanley I.R.  Okoduwa

Stanley I.R. Okoduwa

LiveDNA: 234.30244

Kola M. Anigo

Country: Nigeria

Keywords


  • model rats
  • extract-fractions
  • fruit-mesocarp
  • Balanites aegyptiaca
  • Diabetes
Research Article

Fractionated Ethanol Extract of Balanites aegyptiaca Fruit-Mesocarp Effect on Diabetes Mellitus Model Rats

Daniel H. Mhya Daniel H.  Mhya's LiveDNA, Janet O. Alegbejo, Stanley I.R. Okoduwa Stanley I.R.  Okoduwa's LiveDNA and Kola M. Anigo
Background and Objective: Balanites aegyptiaca fruit is a useful source of hypoglycaemic remedy for management of diabetes in some part of Northern Nigeria. This study evaluated the effects of fractionated ethanol extracts of Balanites aegyptiaca fruit-mesocarp (BAFM) in streptozotocin-induced diabetic rats. Materials and Methods: Ethanol crude extract of BAFM was fractionated with water and ethyl acetate (1:1 v/v) then separated to obtain the specific extract-fraction. The extract-fractions were evaluated for antidiabetic activities in rats induced with diabetes. Diabetes mellitus was induced in male Wistar rats by intra-peritoneal injection of streptozotocin at a dose of 60 mg kg–1 body weight. Results: From the results, rats induced with diabetes were characterized by low serum insulin, hyperglycemia and decrease in body weights. Treatment with the extract-fractions of BAFM elevated serum insulin, lowered fasting blood glucose levels and reversed serum total cholesterol, triglyceride, low density lipoprotein cholesterol and very low density lipoprotein cholesterol levels, serum albumin and total protein. The aqueous fraction (AFF) was more comparable in lowering fasting blood glucose by 18.61% when compared to 24.62% by metformin. A significant increase in serum insulin levels was recorded in diabetic rats treated with AFF when compared to diabetic control rats and diabetic rats treated with ethyl acetate fraction. Conclusion: Both aqueous and ethyl acetate extract-fractions of BAFM exert hypoglycaemic, antihyperglycaemic and antilipidaemic effects. However, the aqueous fraction was more potent. This study is a step towards the isolation of bioactive components. Further research is needed to explore the bioactive component(s) responsible for the antidiabetic effects.
PDF Fulltext XML References Citation

How to cite this article

Daniel H. Mhya, Janet O. Alegbejo, Stanley I.R. Okoduwa and Kola M. Anigo, 2020. Fractionated Ethanol Extract of Balanites aegyptiaca Fruit-Mesocarp Effect on Diabetes Mellitus Model Rats. Asian Journal of Biotechnology, 12: 108-119.

DOI: 10.3923/ajbkr.2020.108.119

URL: https://scialert.net/abstract/?doi=ajbkr.2020.108.119

Related Articles

Red Cell Catalase Activity in Diabetics

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved