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Asian Journal of Biochemistry
  Year: 2020 | Volume: 15 | Issue: 1 | Page No.: 21-27
DOI: 10.3923/ajb.2020.21.27
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Metformin: New Insights into Alzheimer Disease Protection

Rania M. Khalil , Abla Ebeid, Hassan Fayed and Sherien Abd-Elhady

Background and Objective: Alzheimer disease is a major problem continues to increase worldwide. Insulin resistance has recently been implicated in Alzheimer disease pathogenesis as it decreases insulin degrading enzyme and therefore induces the accumulation of amyloid beta. The aim of the study was to explore the effect of metformin in the brain of Alzheimer Disease (AD) rat model. Materials and Methods: Alzheimer disease was induced chemically in rats by adding 6 mg L1 copper sulphate (CuSO4) in drinking water. Metformin-treated group in which (150 mg/kg/day) metformin was given orally to Alzheimer induced rats for 28 days. Rat’s behaviour was assessed by the Morris water maze test. Histopathology of the hippocampus of neurofibrillary tangles, amyloid beta and insulin-degrading enzyme levels were evaluated by enzyme-linked immunosorbent assay in hippocampus tissues. Results: The amyloid beta level was significantly reduced while insulin degrading enzyme level was significantly elevated in the metformin-treated group compared with Alzheimer disease rat model. Conclusion: It is concluded that the findings of the present study have proposed for the first time the potential effect of metformin in protecting against copper producing senile plaques that leads to Alzheimer disease.
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How to cite this article:

Rania M. Khalil, Abla Ebeid, Hassan Fayed and Sherien Abd-Elhady, 2020. Metformin: New Insights into Alzheimer Disease Protection. Asian Journal of Biochemistry, 15: 21-27.

DOI: 10.3923/ajb.2020.21.27






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