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Asian Journal of Biochemistry

Year: 2016 | Volume: 11 | Issue: 2 | Page No.: 82-89
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Authors

Owa Stephen Olugbemiga

Oyewale Damilola Grace

Taiwo Adeolu Adeola

Edewor-Ikupoyi Theresa Ibibia

Okosun Jenifer Akhere

Otohiniyi David Adeiza

Akujobi Yvonne Oluchi

Nwonuma Charles Obiora

Adeyemi Oluyomi Stephen

Adeyemi Oluyomi Stephen

Keywords

Diabetes mellitus is a metabolic disorder affecting about 5-10% of the world’s population. Presently, there is no known cure for diabetes but it could be managed by the use of agents that exhibit hypoglycemic effect. Insulin is a well known agent that has this effect; however, it comes with side effect and contraindications. This underscores the search for newer treatments. The ethanolic extract of Alternanthera pungens was evaluated for antidiabetic and antidyslipidemic properties in alloxan-induced diabetic rats. Thirty five male Wistar rats were assigned into 7 groups of five. All rats, except the negative control group, were induced into diabetes by single intraperitoneal injection of 150 mg kg–1 alloxan. Induced-diabetic rats, apart from the diabetic (positive) control group, were treated daily by oral administration of either glibenclamide at 5 mg kg–1 b.wt., or the ethanolic extract of Alternanathera pungens at 50, 100, 200 and 300 mg kg–1 b.wt. Treatment lasted for 20 days. Data show that the extract treatment significantly reduced the blood glucose to levels lower than in the positive control group. Further, the extract improved the diabetic-related alteration of rat serum lipid profile. The antidiabetic and antidyslipidemic activity of the extract compared competitively with a well-known antidiabetic drug glibenclamide and lends credence to the folk use of Alternanathera pungens.
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How to cite this article

Owa Stephen Olugbemiga, Oyewale Damilola Grace, Taiwo Adeolu Adeola, Edewor-Ikupoyi Theresa Ibibia, Okosun Jenifer Akhere, Otohiniyi David Adeiza, Akujobi Yvonne Oluchi, Nwonuma Charles Obiora and Adeyemi Oluyomi Stephen, 2016. Antidiabetic and Antidyslipidemic Effect of Ethanolic Extract of Alternanathera pungens on Alloxan-Induced Diabetic Rats. Asian Journal of Biochemistry, 11: 82-89.

DOI: 10.3923/ajb.2016.82.89

URL: https://scialert.net/abstract/?doi=ajb.2016.82.89

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