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Asian Journal of Biochemistry
  Year: 2016 | Volume: 11 | Issue: 3 | Page No.: 162-167
DOI: 10.3923/ajb.2016.162.167
 
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Hypoglycemic, Hypolipidemic and Antioxidant Activities of Musa paradisiaca, Normalis (Plantain) Supplemented Diet on Alloxan Induced-diabetic Albino Rats

Friday O. Uhegbu, Chinedu Imo and Chibuzo H. Onwuegbuchulam

Abstract:
Background: This study investigated the effect of unripe Musa paradisiaca (plantain) supplemented diet on serum blood glucose, lipid peroxidation, cholesterol and some antioxidant enzymes on alloxan induced-diabetic albino rats. Materials and Methods: Fifty healthy male albino rats weighing between 86-110 g and aged 6 weeks were used for the study. The rats were placed randomly into five groups of 10 animals each. Group 1 served as control and was not diabetic induced and fed on normal diet. Group 2 served as negative control, they were diabetic induced and fed on normal rat chow. Groups 3-5 were diabetic induced and fed Musa paradisiaca supplemented diet 10, 20 and 30%, respectively for 21 days. Induction of diabetes was by administering intraperitoneally 150 mg kg–1 b.wt., alloxan hydrate to the animals. After 21 days of feeding, animals were starved overnight, anaesthetized with chloroform, killed and blood collected by cardiac puncture. Serum blood glucose, lipid peroxidation, cholesterol and antioxidant enzymes: Superoxide dismutase, catalase, gluthathione-s-transferase and reduced gluthathione were assayed. Data obtained were subjected to one way analysis of variance (ANOVA) and group means were compared using Duncan’s new multiple range tests. Differences were considered to be significant at (p≤0.05). Results: The study reveals that 30% Musa paradisiaca supplemented diet reduced significantly (p≤0.05) serum blood glucose, 223.42±3.65 to 98.54±2.36 mg dL–1, total serum cholesterol and lipid peroxidation levels 149.97±1.35 to 133.23±0.61 mg dL–1 and from 8.96±0.65 to 6.87±0.86 mg dL–1, respectively. Antioxidant enzymes increased significantly (p≤0.05), superoxide dismutase 25.30±3.28 to 32.72±3.68 U L–1, catalase 2.76±0.05 to 3.45±0.11 U L–1, reduced glutathione 2.86±0.41 to 3.86±0.62 U L–1 and gluthatione-s-transferase 6.86±0.86 to 9.76±1.32 U L–1 in the test animals. Conclusion: The plantain supplemented diet elicited hypoglycemic, antilipidemic and antioxidant effects on rats that were fed the diet. The plantain is rich in phytochemicals which may have caused these observed effects and could be of nutritional and clinical importance in the management of diabetes and cardiovascular disease and justices the claim of alternative medicine practitioners that plantain could be used in the management of diabetes.
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How to cite this article:

Friday O. Uhegbu, Chinedu Imo and Chibuzo H. Onwuegbuchulam, 2016. Hypoglycemic, Hypolipidemic and Antioxidant Activities of Musa paradisiaca, Normalis (Plantain) Supplemented Diet on Alloxan Induced-diabetic Albino Rats. Asian Journal of Biochemistry, 11: 162-167.

DOI: 10.3923/ajb.2016.162.167

URL: https://scialert.net/abstract/?doi=ajb.2016.162.167

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