
	Asian Journal of Biochemistry
	Year: 2015 \| Volume: 10 \| Issue: 4 \| Page No.: 173-179 DOI: 10.3923/ajb.2015.173.179

Phytochemicals and Acute Toxicity Profile of Aqueous and Methanolic Extracts of Crateva adansonii Leaves in Swiss Albino Rats

Tsado N. Amos, Lawal Bashir, Santali E. Saba, Mohammed A. Saba, Balarabe M. Mohammed, Ibrahim H. Abdulsalam and George J. Josiah

Abstract: Acute toxicity and phytochemical studies of aqueous and methanolic leaf extract of Crateva adansonii were investigated. The phytochemical screening and acute toxicity studies were conducted using standard procedure and methods. The weights of the rat were monitored before and after the experiment. The phytochemical analyses of the aqueous and methanolic leaf extract of Crateva adansonii leaf showed the presence of alkaloids tannins, flavonoids, saponins cardiac glycoside and steroids in both aqueous and methanolic leaf extract of Crateva adansonii. Phlobatannins were absent in aqueous but present in methanolic leaf extract of Crateva adansonii, while anthraquinones were not detected. The results of the weight changes show that there is no statistically significant (p>0.05) difference in weight gain or weight loss of rat administered with aqueous and methanolic leaf extract of Crateva adansonii as compared with the control group and the LD₅₀ of the aqueous and methanolic leaf extract in rat was found to be greater than 5000 mg kg^-1 body weight. It is concluded that Crateva adansonii contain active phytochemicals of therapeutic potential and that the extract is safe for clinical application.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Antioxidants and Antimicrobial Activities of Methanol Extract of Newbouldia laevis and Crateva adansonii

How to cite this article:

Tsado N. Amos, Lawal Bashir, Santali E. Saba, Mohammed A. Saba, Balarabe M. Mohammed, Ibrahim H. Abdulsalam and George J. Josiah, 2015. Phytochemicals and Acute Toxicity Profile of Aqueous and Methanolic Extracts of Crateva adansonii Leaves in Swiss Albino Rats. Asian Journal of Biochemistry, 10: 173-179.

DOI: 10.3923/ajb.2015.173.179

URL: https://scialert.net/abstract/?doi=ajb.2015.173.179

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library
		Cambridge Scientific Abstract
		FSTA
		Google Scholar

Science Alert