Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Asian Journal of Biochemistry
  Year: 2014 | Volume: 9 | Issue: 4 | Page No.: 179-186
DOI: 10.3923/ajb.2014.179.186
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

In vitro Anticancer Effect of Acanthus ilicifolius on Hepatocellular Carcinoma Cells

E. Rajamanickam, S. Gurudeeban, K. Satyavani and T. Ramanathan

Abstract:
The leading cause of liver cancer is viral infection with hepatitis B and C virus. Liver cancer usually forms inflammation and cirrhosis caused by these viruses. The aim of the study was to investigate anti-liver cancer potential of Acanthus ilicifolius. Powdered leave material was extracted with ethanol and evaluated their anticancer potential on hepatocellular carcinoma cells (HepG2). Treatment with ethanolic extract of A. ilicofolius (AIEE) posses significant changes in cytotoxicity, apoptosis and caspase 3 expressions in HepG2 cells. The results indicated 100 μg mL-1 of AIEE reduced the viability of HepG2 cells in a dose-dependent manner, elevated lactase dehydrogenase and observed condensed chromatin, crooked vesicle shaped membrane in apoptotic nuclei and dead cells appeared bright orange. The expression of caspase 3 was decreased. This study demonstrates the A. ilicofolius have a potent anticancer source. Further analytical studies will be exploring the active constituents in holy mangrove.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Chemopreventive Effect of Acanthus ilicifolius Extract on Modulating Antioxidants, Lipid Peroxidation and Membrane Bound Enzymes in Diethyl Nitrosamine Induced Liver Carcinogenesis
How to cite this article:

E. Rajamanickam, S. Gurudeeban, K. Satyavani and T. Ramanathan, 2014. In vitro Anticancer Effect of Acanthus ilicifolius on Hepatocellular Carcinoma Cells. Asian Journal of Biochemistry, 9: 179-186.

DOI: 10.3923/ajb.2014.179.186

URL: https://scialert.net/abstract/?doi=ajb.2014.179.186

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 

Curve Bottom