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Asian Journal of Biochemistry
  Year: 2012 | Volume: 7 | Issue: 1 | Page No.: 54-58
DOI: 10.3923/ajb.2012.54.58
Oxidative Stress In Anti Thyroperoxidase Antibody Positive Hypothyroid Patients
Nivedita Nanda, Zachariah Bobby and Abdoul Hamide

Abstract:
Hypothyroidism is among the most common endocrine disorders in India. One of the most frequent causes of hypothyroidism is the autoimmune thyroid disease characterized by elevated Anti-thyroperoxidase Antibody (TPO Ab). We reported earlier the presence of Oxidative Stress (OS) in hypothyroid patients. In this study, we compared the level of OS in TPO Ab positive hypothyroid patients with TPO Ab negative hypothyroid patients which earlier has not been studied. We recruited untreated hypothyroid patients consecutively from the out patient department. We analyzed their TPO Ab titer, various biochemical and oxidative stress parameters and ultra-sensitive C reactive protein. The thiobarbituric acid reactive substances, an indicator of oxidative stress was significantly higher in TPO Ab positive hypothyroid patients compared to TPO Ab negative cases. TPO Ab titter positively correlated with the OS parameters and extent of low grade inflammation in TPO Ab positive hypothyroid patients. Oxidative stress was found to be more in TPO Ab positive untreated hypothyroid patients in our study indicating that autoimmunity could be one of the mechanisms contributing to the elevated OS level in hypothyroidism.
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How to cite this article:

Nivedita Nanda, Zachariah Bobby and Abdoul Hamide, 2012. Oxidative Stress In Anti Thyroperoxidase Antibody Positive Hypothyroid Patients. Asian Journal of Biochemistry, 7: 54-58.

DOI: 10.3923/ajb.2012.54.58

URL: https://scialert.net/abstract/?doi=ajb.2012.54.58

COMMENTS
14 April, 2012
Anwar Alashtal:
Hi,



As per the below report my TPOAb is above 600 IU/ML in AUG 2009, I was supposed to take 50MCG on daily basis but i did not till date. No clear phisical signs of the problem in my body till date. What do you recomend



Reagards.


Anwar



Report from Anand Diagnostic Laboratory
Dated 11/8/2009


ANTITHYROPEROXIDASE ANTIBODY


REFERENCE RANGE – UPTO 34 IU/ML


OBSERVED VALUES – MORE THAN 600 IU/ML
28 September, 2012
Nivedita Nanda:

When your TPO level is so high it clearly indicates you have to follow medications as instructed by the physician. Our body has a great tolerance limit. Therefore it takes time before physical signs of these problems are detected. one should always adhere to the medicines and the exact dose instructed by the physician and the medicine dosage should be altered as per clinician's instructions.

11 October, 2012
bernie mchugh:
Iwas on eltroxin 100mcg/50mcg alt days for 10 years.
6 months ago i went hyper. now i am taking neo-mercazole 20.
my anti-thyroperoxidase is now >1000.00
i feel sick after taking neo-mercazole.
my dr.tells me to keep taking it.
felt good before i started to take it.
any idea what i should do.
bernie
 
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