Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Asian Journal of Biochemistry
  Year: 2012 | Volume: 7 | Issue: 4 | Page No.: 206-217
DOI: 10.3923/ajb.2012.206.217
Antiangiogenic Activities of Cinnamon, Black and Green Tea Extracts on Experimentally Induced Breast Cancer in Rats
Hafez R. Madkor, Sherif W. Mansour and Mueen A. Khalil

Abstract:
Breast cancer is the most frequent malignancy in women and its metastatic state represent the second most common cause of mortality. Inhibition of angiogenesis is considered to be an important strategy for cancer therapy. The currently available antiangiogenic agents that are used for treatment of breast cancer have serious side effects limiting their chronic use. Therefore, the current study was designed to investigate and compare the antiangiogenic effects of natural food sources; cinnamon, green and black tea on experimentally induced breast cancer in rats using 7,12-dimethylbenz(a)anthracene (DMBA). Animals were randomly divided into eight groups of seven animals each: four healthy groups and four breast cancer groups induced by a single dose of (20 mg kg-1) of DMBA dissolved in 1.0 mL corn oil. Both healthy and breast cancer groups were treated aqueous extract of cinnamon, black and green tea (100 mg kg-1 b.wt. in 1.0 mL distilled water), given for 45 successive days intragastrically. Serum levels of some angiogenic stimulators and inhibitors were estimated using ELISA assays. The results showed significant increases in the serum levels of VEGF, sVEGFR-1 and bFGF in untreated breast cancer group when compared with untreated healthy rats. Also, there was a significant decrease in the serum levels of VEGF, sVEGFR-1 and bFGF in the treated groups with plants extracts when compared with breast cancer control group. The results of the present study suggested that extracts of these plants have antiangiogenic protective activities and supports the hypothesis that these plants help in the prevention of breast cancer.
 [Fulltext PDF]   [Fulltext HTML]   [XML: Abstract + References]   [References]   [View Citation]  [Report Citation]
 RELATED ARTICLES:
  •    Is Macromastia a Risk Factor for Breast Cancer? A Study on 198 Patients
How to cite this article:

Hafez R. Madkor, Sherif W. Mansour and Mueen A. Khalil, 2012. Antiangiogenic Activities of Cinnamon, Black and Green Tea Extracts on Experimentally Induced Breast Cancer in Rats. Asian Journal of Biochemistry, 7: 206-217.

DOI: 10.3923/ajb.2012.206.217

URL: https://scialert.net/abstract/?doi=ajb.2012.206.217

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 

Curve Bottom