Anti-carcinogenic Effect of Solanum trilobatum in Diethylnitrosamine Induced and Phenobarbital Promoted Heaptocarcinogenesis in Rats


	Asian Journal of Biochemistry
	Year: 2011 \| Volume: 6 \| Issue: 1 \| Page No.: 74-81 DOI: 10.3923/ajb.2011.74.81

Anti-carcinogenic Effect of Solanum trilobatum in Diethylnitrosamine Induced and Phenobarbital Promoted Heaptocarcinogenesis in Rats

M.S. Jahan, G. Vani and C.S. Shyamaladevi

Abstract: Aim of the study is found the anticancer effect of ST on chemically induced hepatocellular carcinoma. The methanolic extract of Solanum trilobatum (ST) prevented 2 stage carcinogenesis in Wistar rats induced by diethyl nitrosamine (DEN) and promoted with Phenobarbital (PB). Animals were induced for hepatic carcinoma with DEN (200 mg kg^-1 b.wt. i.p.,), promoted with PB (0.05%) in basal diet for a period of 3 and 6 months. Animals were also co-treated with methanolic extract of ST (250 mg kg^-1 b.wt. in DMSO orally) for the same period of time (DEN+PB+ST). Administration of ST significantly decreased the levels of tumor markers-carcinoembroynic antigen (CEA) and α-fetoprotein (AFP) in serum compared to their untreated counterparts and also favorably altered the marker enzymes AST, ALT, ALP, GGT and LDH in both serum and liver and 5’nucleotidase in liver. These results show the antitumor effect of ST against DEN induced hepatocarcinogenesis.

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How to cite this article:

M.S. Jahan, G. Vani and C.S. Shyamaladevi, 2011. Anti-carcinogenic Effect of Solanum trilobatum in Diethylnitrosamine Induced and Phenobarbital Promoted Heaptocarcinogenesis in Rats. Asian Journal of Biochemistry, 6: 74-81.

DOI: 10.3923/ajb.2011.74.81

URL: https://scialert.net/abstract/?doi=ajb.2011.74.81

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