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Asian Journal of Biochemistry
  Year: 2011 | Volume: 6 | Issue: 6 | Page No.: 426-438
DOI: 10.3923/ajb.2011.426.438
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Antiulcer Effects of Alpha Lipoic Acid on Gastric Acid Secretion and Mucosal Defense Factors in Rats

M.A. Abd El-Kader, M.M. Ali, N.M. El-Sammad and M.A. El-Shaer

Non steroidal anti-inflammatory drugs are widely used and effective against inflammatory diseases. However, its clinical use is limited by its ulcerogenic effect. This study aimed to investigate the possible gastroprotective effect of alpha-lipoic acid on indomethacin-induced gastric ulcer in rats. Forty adult male Dawley rats were assigned into five groups of eight animals each : group 1 served as control, group 2 was treated intraperitioneally (i.p.) with alpha-lipoic acid (20 mg kg-1 b.w./day) for 7 successive days, group 3: Rats were treated i.p. with indomethacin (20 mg kg-1 b.w./day) for two days, group 4 were treated with indomethacin for 2 days followed by alpha-lipoic acid for 7 days, group 5: Animals were treated with alpha-lipoic acid for 3 days followed by indomethacin for 2 days then alpha-lipoic acid for other 4 days. Alteration of gastric mucosa were analysis. Gastric secretion volume, pH and gastric mucus secretion were determined. In addition, lipid peroxidation and the changes in the antioxidants: reduced glutathione, catalase and superoxide dismutase as markers for antioxidant activity and mucosal defense factors were evaluated. Administration of indomethacin per os induced gastric damage as evidenced by observed ulcers, histological changes, increased gastric secretion volume, decreased pH value and mucus secretion. Alpha lipoic acid were recovered rats from gastric mucosal lesions caused by indomethacin and protected the gastric mucosa covered the stomach wall from injury through decreasing gastric secretion volume, increasing pH value and mucus secretion. All parameters indicating the oxidative injury in gastric mucosa markedly reversed by alpha-lipoic acid treatment due to its potent antioxidant properties where it reduced the level of lipid peroxidation product malondialdehyde, alleviated increases in the catalase activity and ameliorated depressions in reduced glutathione level and the activity of superoxide dismutase caused by indomethacin injection. The results indicate that beneficial effect of alpha-lipoic acid in the protection and treatment of gastric ulcer which result from toxic effect of reactive oxygen species induced by indomethacin.
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How to cite this article:

M.A. Abd El-Kader, M.M. Ali, N.M. El-Sammad and M.A. El-Shaer, 2011. Antiulcer Effects of Alpha Lipoic Acid on Gastric Acid Secretion and Mucosal Defense Factors in Rats. Asian Journal of Biochemistry, 6: 426-438.

DOI: 10.3923/ajb.2011.426.438






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