Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Asian Journal of Biochemistry
  Year: 2011 | Volume: 6 | Issue: 4 | Page No.: 366-372
DOI: 10.3923/ajb.2011.366.372
Insulin Resistance and Interleukin-1β During Normal Pregnancy
Abdolreza Sotoodeh Jahromi, Parvin Zareian and Abdolhossein Madani

Abstract:
The purpose of this study was to evaluate the role of Interleukin-1β (IL-1β) in Insulin Resistance (IR) during normal pregnancy. This cross sectional study was carried out on 86 healthy pregnant women including 26, 23 and 37 individuals in the 1st, 2nd and 3rd trimesters, respectively and in 21 healthy non pregnant women. Serum IL-1β and resistin concentrations were measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Insulin resistance value was calculated using the homeostasis model assessment, (Homeostasis Model Assessment) HOMA-IR. Serum resistin concentration was found to be significantly raised in the second and third trimester as compared with women with first trimester of pregnancy but it was not found any statistical difference in serum resistin concentration between the healthy controls and pregnant women. There was no difference in IL-1β level between pregnant 1.32±0.48 ng mL-1 and non pregnant women 1.44±0.49 ng mL-1. IL-1β level were significantly decreased with increase in gestational age. Pregnant women exhibited higher score of HOMA-IR 2.1±0.9 compared non pregnant women 1.7±0.4 but there were not difference in this score between pregnant subjects in different gestational age. There was not any correlation between maternal gestational age and serum level of IL-1β. The findings of this study suggest that IL-1β do not appear to contribute greatly to pregnancy induced insulin resistance in healthy pregnancy.
 [Fulltext PDF]   [Fulltext HTML]   [XML: Abstract + References]   [References]   [View Citation]  [Report Citation]
 RELATED ARTICLES:
  •    A Randomized Controlled Clinical Trial Investigating the Effect of Calcium Supplement Plus Low-dose Aspirin on hs-CRP, Oxidative Stress and Insulin Resistance in Pregnant Women at Risk for Pre-eclampsia
  •    Effect of Calcium-vitamin D Supplementation on Metabolic Profiles in Pregnant Women at Risk for Pre-eclampsia: A Randomized Placebo-controlled Trial
  •    Serum Leptin and Adiponectin in Obese Diabetic and Non-Diabetic
  •    Hypoadiponectinaemia in Egyptian Patients with Type II Diabetes Mellitus with Vascular Complications
  •    A Systematic Account of Pathogenesis, Diagnosis and Pharmacotherapy of Metabolic Syndrome: Things We Need to Know
  •    Effects of Nitric Oxide on Glucose Transport: in vivo and in vitro Studies
How to cite this article:

Abdolreza Sotoodeh Jahromi, Parvin Zareian and Abdolhossein Madani, 2011. Insulin Resistance and Interleukin-1β During Normal Pregnancy. Asian Journal of Biochemistry, 6: 366-372.

DOI: 10.3923/ajb.2011.366.372

URL: https://scialert.net/abstract/?doi=ajb.2011.366.372

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 

Curve Bottom