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Asian Journal of Biochemistry
  Year: 2011 | Volume: 6 | Issue: 3 | Page No.: 228-239
DOI: 10.3923/ajb.2011.228.239
Study of Serum Lipid Profile and Magnesium in Normal Pregnancy and in Pre-Eclampsia: A Case Control Study
Shalini Maksane, Rashmi Ranka, Nitin Maksane and Anjali Sharma

Abstract:
The aim was to evaluate changes in serum magnesium and lipid profile in pre-eclamptics, their correlation with each other and roles of these changes in its Pathophysiology. Serum magnesium levels were determined by Calmagite method and total lipid profile by enzymatic calorimetric method in healthy non pregnant women (Group-1), primigravidas with normal pregnancy (Group-2) and primigravidas with pre-eclampsia (Group-3). Results of Group-2 were compared with Group-1 and results of Group-3 were compared with Group-2. Compared with normal pregnancy, in pre-eclampsia the level of TG (Triglycerides) (p<0.0001) and VLDL-C (Very Low Density Lipoprotein Cholesterol) (p<0.0001), LDL-C (Low Density Lipoprotein Cholesterol) (p<0.012) were significantly increased and HDL-C (High Density Lipoprotein Cholesterol) (p<0.0001) and Mg++ (p<0.001) levels were decreased significantly. In normotensive pregnant women TG (p<0.0001) and VLDL-C (p<0.0001) and HDL-C (p<0.0001) levels were high and LDL-C (p<0.0001) level was low compared to healthy non pregnant women. No significant change could be observed in serum Mg++ in Group-2 as compared to Group-1 (p<0.2636). No significant change could be observed in total cholesterol level in any group. In addition serum TG correlated negatively(r = -0.47) with serum Magnesium in Pre-eclampsia. The inverse correlation between serum Mg++ and serum triglycerides in pre-eclampsia may suggest the role of magnesium in the pathogenesis of pre-eclampsia along with dyslipidemia. During pregnancy, detection of hypomagnesaemia and dyslipidemia early will prevent its metabolic complication and in established pre-eclamptic women it will help in better management of the disease.
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How to cite this article:

Shalini Maksane, Rashmi Ranka, Nitin Maksane and Anjali Sharma, 2011. Study of Serum Lipid Profile and Magnesium in Normal Pregnancy and in Pre-Eclampsia: A Case Control Study. Asian Journal of Biochemistry, 6: 228-239.

DOI: 10.3923/ajb.2011.228.239

URL: https://scialert.net/abstract/?doi=ajb.2011.228.239

 
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