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Asian Journal of Biochemistry
  Year: 2010 | Volume: 5 | Issue: 4 | Page No.: 222-227
DOI: 10.3923/ajb.2010.222.227
Effect of Sub-Acute Intravenous Injection of Endothelin Receptor Agonist IRL-1620 in Mice
M. Chaudhary, R. Sehgal, P. Arora and N. Kharb

Abstract:
The present study was conducted to evaluate effect of sub-acute intravenous injection of ETB receptor agonist IRL-1620 in mice. Swiss albino mice (n = 24, weighing 20-25 g) were divided into two groups (12 animal each), control group (0 μg kg-1) and IRL-1620 treated group (1 μg/kg/min, i.v., for 30 days). Each group was further subdivided into two groups depending on sex of mice having 6 animals each. No significant change in animal body weight, hemogram, liver function test and renal function tests was observed on treatment with IRL-1620. Histological examination of liver was normal and Kidneys showed mild congestion. In conclusion, sub-acute dose (1 μg/kg/min, i.v.,) of endothelin receptor agonist ETB IRL-1620 did not cause toxic effect on liver and kidney.
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How to cite this article:

M. Chaudhary, R. Sehgal, P. Arora and N. Kharb, 2010. Effect of Sub-Acute Intravenous Injection of Endothelin Receptor Agonist IRL-1620 in Mice. Asian Journal of Biochemistry, 5: 222-227.

DOI: 10.3923/ajb.2010.222.227

URL: https://scialert.net/abstract/?doi=ajb.2010.222.227

 
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