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Asian Journal of Biochemistry
  Year: 2009 | Volume: 4 | Issue: 2 | Page No.: 60-67
DOI: 10.3923/ajb.2009.60.67
Nigella sativa Modulates Cytokines Expression in Mature Bovine Adipocytes
M.M. Soliman, Y.A. El-Fattah El-Senosi, O.M.A. El-Hamid, A.El-Desouki Abd El-Mageed, R.S. Ismaeil and H.A. El-Maqsoud Ali

Abstract:
In this study, we examined the effect of either lipopolysaccharide (LPS, 1 μg mL–1), Nigella.sativa extract (NS, 5 μg mL–1), or co-treatment of both for 24 h on cytokines expression in mature bovine adipocytes using RT-PCR analysis. The results showed that separate treatment by LPS and NS stimulated the expression of interleukin-1 (IL-1β), IL-6, IL-8 and IL-10. Co-treatment of cells by N. sativa with LPS inhibited LPS induced IL-6 and TNF-α expression and induced additive stimulatory effect on LPS induced IL-8 and IL-10 expression. The results indicate that N. sativa extract has immuno-modulatory effect on bovine adipocytes by stimulating different cytokines expression that potentiate different inflammatory and anti-inflammatory functions in bovine adipocytes.
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How to cite this article:

M.M. Soliman, Y.A. El-Fattah El-Senosi, O.M.A. El-Hamid, A.El-Desouki Abd El-Mageed, R.S. Ismaeil and H.A. El-Maqsoud Ali, 2009. Nigella sativa Modulates Cytokines Expression in Mature Bovine Adipocytes. Asian Journal of Biochemistry, 4: 60-67.

DOI: 10.3923/ajb.2009.60.67

URL: https://scialert.net/abstract/?doi=ajb.2009.60.67

 
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