
	Asian Journal of Biochemistry
	Year: 2008 \| Volume: 3 \| Issue: 5 \| Page No.: 308-314 DOI: 10.3923/ajb.2008.308.314

Hepatoprotective Activity of Bi-Herbal Ethanolic Extract on CCl₄ Induced Hepatic Damage in Rats

P. Samudram, H. Rajeshwari, R. Vasuki, A. Geetha and P. Sathiya Moorthi

Abstract: The combined hepatoprotective effect of Bi-Herbal Ethanolic Extract (BHEE) pretreatment against carbon tetra chloride (CCl₄) induced hepatic damage in rats was investigated. Ethanolic extract from the leaves of Melia azedarach and seeds of Piper longum at a dose level of 50 mg kg^-1 body weight was administered orally daily once for 14 days, prior to the administration of 0.2 mL of CCl₄ kg^-1 body weight for 7 days. The substantially elevated serum marker enzymes such as Serum glutamic Oxaloacetic Transaminase (SGOT), Serum Glutamic Pyruvic Transaminase (SGPT), Alkaline Phosphatase (ALP), Acid Phosphatase (ACP), Lactatedehydrogenase (LDH), Gamma glutamyl Transferase (Î³GT) and 5 Nucleotidase (5NT), due to CCl₄ treatment were restored towards normalization in rats pretreated with BHEE. The determination of liver weight and biochemical parameters such as serum bilirubin and blood urea showed a remarkable decrease in rats pre- treated with the BHEE when compared with those administered CCl₄alone. In addition BHEE significantly increased the total protein, total cholesterol and triglyceride also towards normal levels. Silymarin at a dose level of 50 mg kg^-1 was used as a standard reference also exhibited significant hepatoprotective activity against CCl₄induced hepatotoxicity. The results of this study strongly indicate that BHEE has got a potent hepatoprotective action against CCl₄induced hepatic damage in rats.

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How to cite this article:

P. Samudram, H. Rajeshwari, R. Vasuki, A. Geetha and P. Sathiya Moorthi, 2008. Hepatoprotective Activity of Bi-Herbal Ethanolic Extract on CCl₄ Induced Hepatic Damage in Rats. Asian Journal of Biochemistry, 3: 308-314.

DOI: 10.3923/ajb.2008.308.314

URL: https://scialert.net/abstract/?doi=ajb.2008.308.314

COMMENTS

14 August, 2011
Dr. N.jagan rao:
Very good research finding,which will be of immense use towards further research on role of herbal medicines in treatment of hepatoprotective activity.

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Hepatoprotective Activity of Bi-Herbal Ethanolic Extract on CCl₄ Induced Hepatic Damage in Rats