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Asian Journal of Biochemistry
  Year: 2008 | Volume: 3 | Issue: 3 | Page No.: 182-187
DOI: 10.3923/ajb.2008.182.187
Complementary Hypoglycemic and Anti-Hyperglycemic Activity of Various Extracts of Fenugreek Seeds in Rats
Mukesh Yadav, Radha Tomar, GBKS Prasad, Shalini Jain and Hariom Yadav

Abstract:
In present study, five extracts of fenugreek seed with different solvents (water, ethanol, methanol, hexane and chloroform) alone and in combination with glimepiride were tested for hypoglycemic and anti-hyperglycemic activity in rats by screening blood glucose for 6 h. Water extract exhibited highest hypoglycemic and anti-hyperglycemic activity in rats among all the extracts, while hexane and other extracts exhibited least and moderate activity, respectively. Water extract was further studied to dose dependent [200, 100 and 50 mg kg-1 body weight (b.wt.)] hypoglycemic and anti-hyperglycemic effects alone and in combination with glimepiride (20, 10 and 5 mg kg-1 b.wt.). The combination of water extract (200 mg kg-1 b.wt.) and lower dose of glimepiride (5 mg kg-1 b.wt.) has shown safer and potent hypoglycemic as well as anti-hyperglycemic activity and not created severe hypoglycemia in normal rats, while higher doses (200 mg kg-1 b.wt. of water extract and 10 and 20 mg kg-1 b.wt. of glimepiride) were generated lethal hypoglycemia in normal rats. The results of present study enforced to say that, the water extract of fenugreek seeds has higher hypoglycemic and anti-hyperglycemic potential and may use as a complementary medicine to treat the diabetic hyperglycemia by significantly reducing dose of standard drugs.
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How to cite this article:

Mukesh Yadav, Radha Tomar, GBKS Prasad, Shalini Jain and Hariom Yadav, 2008. Complementary Hypoglycemic and Anti-Hyperglycemic Activity of Various Extracts of Fenugreek Seeds in Rats . Asian Journal of Biochemistry, 3: 182-187.

DOI: 10.3923/ajb.2008.182.187

URL: https://scialert.net/abstract/?doi=ajb.2008.182.187

 
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