
	Asian Journal of Biochemistry
	Year: 2007 \| Volume: 2 \| Issue: 4 \| Page No.: 247-255 DOI: 10.3923/ajb.2007.247.255

Protective Effect of Solanum surattense Leaf-Extract on Blood Glucose, Oxidative Stress and Hepatic Marker Enzymes in STZ-Diabetic Rats

M. Sridevi , G. Chandramohan and K.V. Pugalendi

Abstract: In this study, the protective effect of alcoholic leaf extract of Solanum surattense on blood glucose and redox status in streptozotocin (STZ)-induced diabetic rats has been evaluated. Diabetes was induced in adult male albino Wistar rats weighing 180-200 g, by the administration of STZ (40 mg kg^-1 body weight) intraperitoneally. The diabetic rats showed elevated levels of blood glucose and a significant decrease in plasma insulin levels. The increased levels of lipid peroxidation markers such as thiobarbituric acid reactive substances (TBARS), conjugated dienes (CD) and lipid hydroperoxides (LOOH) were observed in diabetic rats. The activities of enzymatic antioxidants (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glucose 6-phosphate dehydrogenase) and the levels of non-enzymatic antioxidants, (reduced glutathione (GSH) and vitamin C) decreased, whereas, vitamin E increased in the erythrocytes of diabetic rats. Plasma hepatic marker enzymes also increased in STZ-diabetic rats. Oral administration of S. surattense leaf extract (100 mg kg^-1 b.wt.) reversed these parameters towards normalcy. Thus, our results indicate that the S. surattense leaf extract possesses antihyperglycemic, antilipidperoxidative and hepatoprotective and antioxidant potential in diabetic rats.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Determination of Processing Effects on Phytochemical Content, Antioxidants Activity and Chemopreventive Potential of Beets (Beta vulgaris) using a Colon Cancer Fisher 344 Male Rat Model

•	Methanolic Root Extract of Olax viridis Protects the Liver against Acetaminophen-induced Liver Damage

•	Synergistic Effects of Glutathione and Vitamin E on ROS Mediated Ethanol Toxicity in Isolated Rat Hepatocytes

How to cite this article:

M. Sridevi , G. Chandramohan and K.V. Pugalendi , 2007. Protective Effect of Solanum surattense Leaf-Extract on Blood Glucose, Oxidative Stress and Hepatic Marker Enzymes in STZ-Diabetic Rats. Asian Journal of Biochemistry, 2: 247-255.

DOI: 10.3923/ajb.2007.247.255

URL: https://scialert.net/abstract/?doi=ajb.2007.247.255

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library
		Cambridge Scientific Abstract
		Chemical Abstract Services
		FSTA
		Google Scholar

Science Alert