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Asian Journal of Biochemistry
  Year: 2007 | Volume: 2 | Issue: 4 | Page No.: 224-236
DOI: 10.3923/ajb.2007.224.236
 
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Acute and Sub-chronic Toxicity Studies of Crude Aqueous Extract of Albizzia chevalieri Harms (Leguminosae)
Y. Saidu , L.S. Bilbis , M. Lawal , S.A. Isezuo , S.W. Hassan and A.Y. Abbas

Abstract:
The current study reports the toxicological studies of the crude aqueous leaf extract using albino rat models. The in vivo effects of acute and sub-chronic doses of the extract on liver function and kidney function parameters were studied. The results indicated that the LD50 of the extract is > 3000 mg kg-1 body weight. There were no significant differences (p>0.05) in weight changes of the animals on different doses of the extract during both the acute and sub-chronic toxicity tests. The biochemical parameters of the animals on different doses of the extract were not significantly (p>0.05) different, except the ALT and AST that, in non-dose dependence, showed significant differences (p<0.05) in both test models. Serum globulin level of the animals on different doses during the sub-chronic test was also significantly different (p<0.05). These results indicated that the crude extract of A. chevalieri may be relatively safe for human consumption.
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How to cite this article:

Y. Saidu , L.S. Bilbis , M. Lawal , S.A. Isezuo , S.W. Hassan and A.Y. Abbas , 2007. Acute and Sub-chronic Toxicity Studies of Crude Aqueous Extract of Albizzia chevalieri Harms (Leguminosae). Asian Journal of Biochemistry, 2: 224-236.

DOI: 10.3923/ajb.2007.224.236

URL: https://scialert.net/abstract/?doi=ajb.2007.224.236

 
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