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Asian Journal of Biochemistry
  Year: 2006 | Volume: 1 | Issue: 1 | Page No.: 47-56
DOI: 10.3923/ajb.2006.47.56
 
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Quantitative Structure-activity Relationship Studies on Benzodiazepine Hydroxamic Acid Inhibitors of Matrix Metalloproteinases and Tumor Necrosis Factor-α Converting Enzyme

S.P. Gupta and S. Kumaran

Abstract:
A Quantitative Structure-activity Relationship (QSAR) study has been made on the inhibitions of some Matrix Metalloproteinases (MMPs) and Tumor Necrosis Factor-α Converting Enzyme (TACE) by benzodiazepine hydroxamic acid inhibitors. It has been found that there exits an inverse parabolic relationship between the hydrophobicity (logP) and inhibition activities of compounds for certain series of inhibitors against MMP-1 and MMP-13, suggesting that inhibition mechanism of these enzymes could be allosteric. The appearance of E-state index of nitrogen atom (SN) attached to sulfonyl group in the equations derived for MMP-9, MMP-13 and TACE reveals that there can be some electronic interaction also between the inhibitors and these enzymes.
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How to cite this article:

S.P. Gupta and S. Kumaran , 2006. Quantitative Structure-activity Relationship Studies on Benzodiazepine Hydroxamic Acid Inhibitors of Matrix Metalloproteinases and Tumor Necrosis Factor-α Converting Enzyme. Asian Journal of Biochemistry, 1: 47-56.

DOI: 10.3923/ajb.2006.47.56

URL: https://scialert.net/abstract/?doi=ajb.2006.47.56

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