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Asian Journal of Biochemistry
  Year: 2006 | Volume: 1 | Issue: 3 | Page No.: 257-261
DOI: 10.3923/ajb.2006.257.261
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Impaired Activity of Serum Alpha 1-protease Inhibitor in Diabetes Mellitus
M. Naderi, M. Hashemi and S. Ghavami

Alpha-1-antitrypsin (AAT) is the prototypic member of the serine protease inhibitor (serpin) superfamily of proteins, which have a major role in inactivating neutrophil elastase and other proteases to maintain protease-antiprotease balance. In this study the serum AAT was measured using enzymatic assay in diabetic patients. The serum trypsin inhibitory capacity (s-TIC) was determined in 144 outpatients with uncontrolled insulin-dependent diabetes mellitus (n = 39) and non insulin dependent diabetes mellitus (n = 104). The s-TIC values were 1.960±0.399, 2.002±0.4304 and 2.867±0.395 μmol min-1 mL-1 in IDDM, NIDDM and healthy subjects, respectively. The diabetics groups had a significantly lower s-TIC in their serum than did the healthy control (p<0.0001). We found that there is a negative correlation between s-TIC and the duration of diabetes disease (r = -0.5420; p<0.0001). There was no correlation between S-TIC and age of patients (p = 0.865). We found that in diabetic patients, glucose dysregulation have significant effects on the trypsin inhibitory capacity of plasma.
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How to cite this article:

M. Naderi, M. Hashemi and S. Ghavami, 2006. Impaired Activity of Serum Alpha 1-protease Inhibitor in Diabetes Mellitus. Asian Journal of Biochemistry, 1: 257-261.

DOI: 10.3923/ajb.2006.257.261








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