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Asian Journal of Biochemistry
  Year: 2006 | Volume: 1 | Issue: 3 | Page No.: 244-250
DOI: 10.3923/ajb.2006.244.250
Correlation Between Frequent Risk Factors of Diabetic Nephropathy and Serum Sialic Acid
Syed Muhammad Shahid and Tabassum Mahboob

Abstract:
It is recently established that serum sialic acid is a potent cardiovascular and renal risk factor in general population and also found elevated in diabetic type 2 patients. This study was designed to assess the coexistence of frequently documented risk factors of diabetic nephropathy with serum sialic acid. A total of 100 diabetic patients (50 with and 50 without nephropathy) aged 47.56±10.68 (mean±SD) year attending several diabetic clinics of private sector in Karachi were included after informed consent was obtained. Systolic and diastolic blood pressures were recorded by standard mercury sphygmomanometer. Fasting blood samples were collected for the estimations of blood glucose, HbA1c, serum urea, creatinine and sialic acid levels. Serum sialic acid, glucose, HbA1c, urea and creatinine levels were increased significantly (p<0.01) in diabetic nephropathy patients as compared to diabetic patients without nephropathy. Regression and correlation analysis showed a significant positive correlation between serum sialic acid and fasting blood glucose, HbA1c, serum urea and creatinine levels. BMI and blood pressures were also significantly high in diabetic patients with nephropathy as compared to those without nephropathy. Fifty four percent diabetic nephropathy patients were found to be smokers where as 41% were smokers in diabetic patients without nephropathy. It is concluded that the elevated serum sialic acid level is strongly associated with the presence of microvascular complications of diabetes, nephropathy for example. There is a significant unvaried link between serum sialic acid and diabetic nephropathy. The consideration of sialic acid as potent disease marker for diabetic nephropathy is therefore justified.
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How to cite this article:

Syed Muhammad Shahid and Tabassum Mahboob, 2006. Correlation Between Frequent Risk Factors of Diabetic Nephropathy and Serum Sialic Acid. Asian Journal of Biochemistry, 1: 244-250.

DOI: 10.3923/ajb.2006.244.250

URL: https://scialert.net/abstract/?doi=ajb.2006.244.250

 
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