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Asian Journal of Biochemistry
  Year: 2006 | Volume: 1 | Issue: 3 | Page No.: 211-223
DOI: 10.3923/ajb.2006.211.223
Quantitative Structure-Activity Relationship Studies on Matrix Metalloproteinase Inhibitors: Piperazine, Piperidine and Diazepine Hydroxamic Acid Analogs
S.P. Gupta and S. Kumaran

Abstract:
A quantitative structure-activity relationship study has been made on four different series of piperazine, piperidine and diazepine hydroxamic acid analogs acting as matrix metalloproteinase (MMP) inhibitors. The results suggest that in most of the cases the hydrophobic property of the molecules plays a major role in the inhibition of the enzymes MMP-1, MMP-9, MMP-13 and TACE. In many cases, MMP-9 and MMP-13 are shown to behave in a similar fashion with the different group of inhibitors.
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How to cite this article:

S.P. Gupta and S. Kumaran, 2006. Quantitative Structure-Activity Relationship Studies on Matrix Metalloproteinase Inhibitors: Piperazine, Piperidine and Diazepine Hydroxamic Acid Analogs. Asian Journal of Biochemistry, 1: 211-223.

DOI: 10.3923/ajb.2006.211.223

URL: https://scialert.net/abstract/?doi=ajb.2006.211.223

 
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