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Asian Journal of Animal and Veterinary Advances
  Year: 2022 | Volume: 17 | Issue: 4 | Page No.: 146-156
DOI: 10.3923/ajava.2022.146.156
 
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Ganoderma boninense (Ganodermataceae) Aqueous Extract Protects Against Liver and Reproductive Alterations in Parastar-Exposed Male Wistar Rats

Tangu Nehemiah Njegwe, Kada Sanda Antoine, Kaghou Mabel Mbifung, Njouonkou André-Ledoux, Manfo Tsagué Faustin Pascal , Nono Vanessa Ninkeh, Mbouh Mariama and Nantia Akono Edouard

Abstract:
Background and Objective: Pesticides largely used in agriculture and public health hygiene have shown negative effects on mammalian systems. Mushrooms thanks to their content in bioactive compounds have been considered as promising pharmacological sources. This study aimed at evaluating the protective effects of Ganoderma boninense aqueous extract (GBE) on the liver and reproductive parameters in Parastar-exposed male Wistar rats. Materials and Methods: Forty eight male rats (150±2 g) equitably divided into 6 groups were given either distilled water (5 mL kg–1), Parastar (6.23 mg kg–1), GBE (50, 150 mg kg–1) or Parastar (6.23 mg kg–1) and GBE (50, 150 mg kg–1) for 60 days. At the end of treatment, liver and reproductive organs weights were recorded and epididymal sperm characteristics determined. Liver and testis histology and biomarkers (testosterone levels, oxidative stress biomarkers, vesicular fructose) were also evaluated. Results: Treatment of animals with Parastar resulted in a decrease (p<0.05) of liver weights and increased (p<0.05) activities of alanine and aspartate aminotransferases. The insecticide decreased (p<0.05) epididymal sperm density and motility, serum testosterone and vesicular fructose levels. Moreover, Parastar increased lipid peroxidation, decreased glutathione levels, superoxide dismutase and catalase activities and induced histopathological changes in the testis and liver. Interestingly, all Parastar altered liver and reproductive parameters were counteracted with the co-administration of any of the two doses of GBE. Conclusion: This study provides evidence that G. boninense is a promising mushroom in protecting the liver and reproductive functions against Parastar-induced toxicity.
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How to cite this article:

Tangu Nehemiah Njegwe, Kada Sanda Antoine, Kaghou Mabel Mbifung, Njouonkou André-Ledoux, Manfo Tsagué Faustin Pascal, Nono Vanessa Ninkeh, Mbouh Mariama and Nantia Akono Edouard, 2022. Ganoderma boninense (Ganodermataceae) Aqueous Extract Protects Against Liver and Reproductive Alterations in Parastar-Exposed Male Wistar Rats. Asian Journal of Animal and Veterinary Advances, 17: 146-156.

DOI: 10.3923/ajava.2022.146.156

URL: https://scialert.net/abstract/?doi=ajava.2022.146.156

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