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Asian Journal of Animal and Veterinary Advances

Year: 2020 | Volume: 15 | Issue: 1 | Page No.: 1-12
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Authors

Elham A. Abd-Allah

Elham A. Abd-Allah

Ahlam A. Alahmadi

Hanan S.A. Waly

Bassam A. Alahmadi

Keywords

Research Article

Anti-inflammatory Properties of Curcumin May Be Useful for Treating the Deleterious Effects of CCL4 on Liver and Spleen

Elham A. Abd-Allah Elham A. Abd-Allah's LiveDNA, Ahlam A. Alahmadi, Hanan S.A. Waly and Bassam A. Alahmadi
Background and Objective: Curcumin (CUR) is the main ingredient of turmeric, has been confirmed to possess anti-inflammatory and anti-oxidative characteristics. Liver diseases are a global health issue as the liver is the essential detoxifying organ. We conducted our study to verify the protective effects of CUR against carbon tetrachloride (CCL4), which stimulates liver and spleen injury in mice. Materials and Methods: Thirty adult male mice were randomly divided into 3 groups (8-10 mice/group). First group served as control group, second one intraperitoneally injected with CCL4 (0.1 mL kg–1, i.p.). The third group intraperitoneally injected with CCL4 (0.1 mL kg–1) and co-treated with curcumin (200 mg kg–1) intragastrically, the experiment continued for 8 weeks, 3 times/weekly. Results: The CCL4 increased serum liver enzymes (ALT, AST and ALP), mRNA expression levels of TNF-α, IL-1 and IL-6 were detected as pro-inflammatory markers and 5LO, NOX2 and COX-2 as inflammatory biomarkers for liver and spleen, significant elevations was detected in LPO levels. GSH, GST, GPx, CAT and SOD levels as antioxidants were significantly lessened. Histopathological alterations were also detected. Interestingly, curcumin supplementation of CCL4 treated group decreased expression of inflammatory markers as well as improved antioxidant status and histoarchitecture in liver and spleen. Conclusion: This data suggested that curcumin protect the liver and spleen from acute CCL4 induced injury in a rodent model by suppressing hepatic and splenic oxidative stress expression levels of inflammatory markers. Therefore, curcumin are potential therapeutic antioxidant agents against acute hepatotoxicity and spleenotoxicity.
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How to cite this article

Elham A. Abd-Allah, Ahlam A. Alahmadi, Hanan S.A. Waly and Bassam A. Alahmadi, 2020. Anti-inflammatory Properties of Curcumin May Be Useful for Treating the Deleterious Effects of CCL4 on Liver and Spleen. Asian Journal of Animal and Veterinary Advances, 15: 1-12.

DOI: 10.3923/ajava.2020.1.12

URL: https://scialert.net/abstract/?doi=ajava.2020.1.12

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