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  1. Asian Journal of Animal and Veterinary Advances
  2. Vol 11 (6), 2016
  3. 363-370
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Asian Journal of Animal and Veterinary Advances

Year: 2016 | Volume: 11 | Issue: 6 | Page No.: 363-370
DOI: 10.3923/ajava.2016.363.370

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Authors


Soontaree Petchdee

Country: Thailand

Worawit Suphamungmee

Country: Thailand

Ratikorn Bootcha

Country: Thailand

Keywords


  • Dental pulp stem cells
  • osteoarthritis
  • stifle joint
  • rabbit
Research Article

Therapeutic Benefit of Intra-articular Administration of Deciduous Teeth Stem Cells in Rabbit Model of Osteoarthritis

Soontaree Petchdee, Worawit Suphamungmee and Ratikorn Bootcha
Background and Objective: Stem cell therapy is a new treatment option for osteoarthritis. A various applications of stem cell therapy have been used for cartilage regeneration in arthritis patient. The objective of this study was to examine therapeutic effects of puppy deciduous teeth stem cells for the treatment of osteoarthritis using a rabbit model.Methodology: In this study, rabbits were subjected to perform osteoarthritis. The anterior cruciate ligament of the stifle joint was transected over 3 months in order to generate the knee osteoarthritis. Puppy deciduous teeth stem cells were intra-articularly introduced in a test group after surgically induced arthritis. Histological characteristic of stifle joint was observed at the end of each experiment for obtaining the therapeutic effects regarding the stem cell treatment. Results: Results showed an increased number of chondrocytes and the cartilaginous thickening of articular cartilage layer in the puppy deciduous teeth stem cells-injected group. Conclusion: This finding will open a marked discussion for future possibility in using deciduous teeth stem cells as an alternative procedure for osteoarthritis treatment.
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How to cite this article

Soontaree Petchdee, Worawit Suphamungmee and Ratikorn Bootcha, 2016. Therapeutic Benefit of Intra-articular Administration of Deciduous Teeth Stem Cells in Rabbit Model of Osteoarthritis. Asian Journal of Animal and Veterinary Advances, 11: 363-370.

DOI: 10.3923/ajava.2016.363.370

URL: https://scialert.net/abstract/?doi=ajava.2016.363.370

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