Submit Manuscript

Asian Journal of Animal and Veterinary Advances

Year: 2011 | Volume: 6 | Issue: 9 | Page No.: 935-943
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 107

Authors

Yanyan Ke

Wenjie Liu

Zixu Wang

Yulan Dong

Yaoxing Chen

Keywords

Research Article

The Role of Sympathectomy on the Distribution of Intraepithelial Lymphocyte, Mast Cell, IgA+, CD4+ and CD8+ Cell in Intestine of Mice

Yanyan Ke, Wenjie Liu, Zixu Wang, Yulan Dong and Yaoxing Chen
The purpose of this study was to determine the role of sympathetic nerves on distribution of the gut immune-associated cells (Including Intraepithelial Lymphocyte (IEL), mast cell, IgA+, CD4+ and CD8+ cell) in small intestine. A model of chemical sympathectomy in mice was established by intraperitoneal injection of 6-hydroxydopamine (6-OHDA). The gut immune-associated cells were investigated by histology and immunohistochemistry method. This study found that from proximal to distal segments in small intestine of normal mice, the numbers of intraepithelial lymphocyte, IgA+ and mast cells decreased gradually, whereas CD4+ and CD8+ cell number increased gradually. When 6-hydroxydopamine (6-OHDA) was intraperitoneally injected into mice, IEL numbers were significantly decreased in whole small intestines. However, IgA+ and mast cell numbers decreased merely in the proximal segment while CD4+ and CD8+ cell numbers and their ratio reduced mainly in the distal segment. These findings indicated that sympathetic denervation disturbed the patterns of gut immune-associated cell distribution. It would substantiate the thesis of neuro-immune-endocrine and provide the new ideas for the intestinal disease prevention and drug developments.
PDF Fulltext XML References Citation

Related Articles

Effects of Chemical Sympathectomy on the Level of Reproductive Hormones and Mast Cells During Mouse Early Pregnancy
Intestinal Humoral Immune Response and Resistance to Salmonella Challenge of Progeny from Breeders Vaccinated with Killed Antigen
Effect of Emblica officinalis Methanolic Fruit Extract on Indomethacin Induced Enterocolitis in Rats
Effect of Dietary Betaine on Performance, Immunocompetence and Gut Contents Osmolarity of Broilers Challenged With a Mixed Coccidial Infection
Probiotic in Quail Nutrition: A Review
A Systematic Review and Meta-analysis of the Efficacy and Adverse Events of Infliximab in Comparison to Corticosteroids and Placebo in Active Ulcerative Colitis

Leave a Comment

Your email address will not be published. Required fields are marked *