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Asian Journal of Animal and Veterinary Advances
  Year: 2011 | Volume: 6 | Issue: 6 | Page No.: 572-579
DOI: 10.3923/ajava.2011.572.579
 
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The Healing Effect of Mixture of Honey, Putty, Vitriol and Olive oil in Pseudomonas aeroginosa Infected Burns in Experimental Rat Model

S.V. Hosseini, H. Niknahad, N. Fakhar, A. Rezaianzadeh and D. Mehrabani

Abstract:
This study was carried out to investigate the healing effect of mixture of honey, putty and vitriol dissolved in olive oil on burn wounds infected with P. aeruginosa in rat as an experimental animal model. From April to July 2008, 60 rats were divided into three equal groups, Group A as control left without any treatment, Group B received mixture of honey, putty and vitriol dissolved in olive oil and Group C received just silver sulfadiazine. A standard 3rd degree burn wound was established and after 24 h, 108 colony forming units of toxigenic strains of P. aeruginosa were inoculated subcutaneously. Samples from infected areas were cultured to identify the bacteria. After 7, 14 and 21 days, the burn areas were studied histologically. Bacterial count of the wound on 2nd day was 105 P. aeruginosa. On day 7, 14 and 21, the number of bacteria in groups B and C significantly decreased in comparison to Group A. Regarding epithelialization on day 7, no significant difference was noticed between groups B and C. On day 14, Group B demonstrated better re-epithelialization than groups A and C. On day 21, best results were observed in Group B but the difference was not significant. On day 21, there was poor re-epithelialization in Group A. The mean score of group C was between A and B groups. Our results showed that our mixture for treatment of burn site was safe and effective. However, to use this mixture clinically, more supportive studies seem necessary.
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How to cite this article:

S.V. Hosseini, H. Niknahad, N. Fakhar, A. Rezaianzadeh and D. Mehrabani, 2011. The Healing Effect of Mixture of Honey, Putty, Vitriol and Olive oil in Pseudomonas aeroginosa Infected Burns in Experimental Rat Model. Asian Journal of Animal and Veterinary Advances, 6: 572-579.

DOI: 10.3923/ajava.2011.572.579

URL: https://scialert.net/abstract/?doi=ajava.2011.572.579

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