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Asian Journal of Animal and Veterinary Advances

Year: 2010 | Volume: 5 | Issue: 3 | Page No.: 202-209
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Authors

M. Cabeza

Y. Heuze

H. Quintana

E. Bratoeff

Keywords

Research Article

Comparison Between Two Different Hamster Models used for the Determination of Testosterone and Finasteride Activity

M. Cabeza, Y. Heuze, H. Quintana and E. Bratoeff
The aim of this study is to compare the effect of Testosterone (T) and finasteride (F)-treatments on the diameter of the pigmented spot of hamster’s flank organs as well as on the weight of seminal vesicles and prostate glands in two different animal models: prepuberal and adult hamsters. The treatments administrated to prepuberal hamsters, after 7 days of castration and adults hamsters after 30 days of castration showed similar results in the growth of prostate and seminal vesicles. However, the flank organs response to finasteride from prepuberal hamster was different than that observed for the flank organs from adult hamsters. Daily injections with T plus F in prepuberal castrated hamsters did not decrease the diameter of the flank organs, thus suggesting that the 5α-reductase enzyme is not present in these glands. In conclusion, the flank organs from prepuberal hamsters are a good model for the determination of the androgenic and antiandogenic activity. However, this assay is not suitable for the determination of 5α-reductase inhibitory activity of different steroids in vivo. Furthermore, both adults and prepuber hamsters prostate and seminal vesicles are good models for the determination of the androgenic, antiandrogenic and 5α-reductase inhibitory effects in drugs.
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