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Asian Journal of Animal and Veterinary Advances
  Year: 2010 | Volume: 5 | Issue: 2 | Page No.: 136-142
DOI: 10.3923/ajava.2010.136.142
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Effects of Silymarin and Food Restriction on Hepatic and Pancreatic Functions in Wistar Rats

A. Dehghan, A.A. Mahjoor, H. Bazyar and K. Zangili

Silymarin, a natural hepatoprotector, extracts from Silybum marianum. It seems that silymarin can modulate metabolic changes in the liver and pancreas, also Food Restriction (FR) affects their metabolism. The aim of the study was the evaluation of concurrent effects of silymarin and food restriction on metabolic functions of liver and pancreas to improve their treatment response. Sixty female Wistar rats were divided into six equal groups. Control group were fed ad libitum (Non-FR). Rats in other groups received 50% of the food intake of Non-FR group and served as FR groups. Three of five FR groups received 100, 200 and 400 mg kg-1 silymarin, respectively. The fourth FR group received placebo. The last FR group and the Non-FR group did not receive any silymarin. Food restriction decreased serum triglycerides in all FR groups (p<0.01). Administration of 100 mg kg-1 of silymarin to FR rats increased serum triglycerides levels (p = 0.02). Food restriction significantly decreased ALT and ALP which may relate to decrease in liver functional mass. The compare of serum amylase levels in FR and Non-FR groups showed that food restriction, except in FR-100 group, decreased these levels (p<0.05). Present results showed no constant change on glucose and triglyceride levels by silymarin. It seems that silymarin is a modulator of metabolic factors, such as glucose and triglyceride, which needs further researches. Also, concurrent use of food restriction and silymarin doesn’t have any adverse effect on pancreas and hepatobiliary system and can be used simultaneously to increase their benefits.
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  •    Silybum marianum L. Despite of its Weedy Nature is an Important Medicinal Plant of NWFP, Pakistan
  •    Effect of Silymarin on Metabolic Factors of Food-Restricted Over Conditioned Wistar Rats
How to cite this article:

A. Dehghan, A.A. Mahjoor, H. Bazyar and K. Zangili, 2010. Effects of Silymarin and Food Restriction on Hepatic and Pancreatic Functions in Wistar Rats. Asian Journal of Animal and Veterinary Advances, 5: 136-142.

DOI: 10.3923/ajava.2010.136.142






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