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Asian Journal of Animal Sciences
  Year: 2020 | Volume: 14 | Issue: 4 | Page No.: 121-126
DOI: 10.3923/ajas.2020.121.126
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Hepatoprotective Activity of Martynia annua L. Leaves Against CCl4-induced Hepatic Damage in Rats

Ashwani K. Dhingra and Bhawna Chopra

Background and Objective: In modern medicine, there is a need for effective and safe hepatoprotective drugs to treat and prevent drug-induced liver damage. Leaves of Martynia annua L., (Martyniaceae) are used traditionally for their hepatoprotective effect. In the present study, methanol extract of Martynia annua L. leaves was selected for the evaluation of hepatoprotective activity owing to its traditional use. Materials and Methods: Hepatic injury in rats was carried out using the CCl4-induced hepatotoxic model. Methanolic extracts of Martynia annua L. were administered orally at two different doses (200 and 400 mg kg1) daily. The biochemical parameters (SGOT, SGPT, ALP and serum bilirubin) were estimated using Reitman and Frankel's method in addition with Kind King’s method. Results: The preliminary phytochemical studies confirmed the existence of glycosides, phenols, carbohydrates, tannins, anthocyanins and flavonoids. The CCl4 treated group showed noteworthy boost the concentrations of Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), alkaline phosphate (ALP) and serum bilirubin as compared to control group (rats treated with vehicle). The methanolic extract of plant 400 mg kg1 and Silymarin 100 mg kg1 indicated major and equipotent (p<0.01) decrease in raised levels of the enzymes. The histopathological examinations of liver sections of rats were supplemented with biochemical observations. Conclusion: The results clearly indicate that Martynia annua L. leaves have notable hepatoprotective activity in rats against hepatic damage induced by CCl4.
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How to cite this article:

Ashwani K. Dhingra and Bhawna Chopra, 2020. Hepatoprotective Activity of Martynia annua L. Leaves Against CCl4-induced Hepatic Damage in Rats. Asian Journal of Animal Sciences, 14: 121-126.

DOI: 10.3923/ajas.2020.121.126






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