Foreign body syndrome of bovine is still a challenge in veterinary practices all over the world. A total of 1536 buffaloes at Nineveh province, Iraq were examined for foreign body syndrome during two years. Based on case history, clinical examination and ferroscopy, foreign body syndrome was initially suspected and subsequently confirmed through rumenotomy in 338 animals and post mortem examination in 13 buffaloes. Morning, evening and daily milk yields (Liters) before and after the onset of Sharp Foreign Body Syndrome (SFBS) was recorded. Data were displayed and analyzed statistically. Out of 1536 examined buffaloes, 351 buffaloes (22.9%) had foreign body syndrome. The most common clinical signs were varying degrees of anorexia, recurrent rumen tympany and decreased milk yield. The mean morning, evening and daily milk yields before SFBS were 2.9±0.2, 2.6±0.2 and 5.5±0.4 and after SFBS were 0.9±0.1, 0.689±0.1 and 1.58±0.2, respectively. Rumenotomy revealed either sharp foreign bodies, both sharp and blunt foreign bodies or blunt foreign bodies in 259 (76.6%), 70 (20.7%) and 9 (2.7%) buffaloes, respectively. The recorded complications in the examined buffaloes were local reticuloperitonitis (n = 231, 65.8%), reticular abscess (n = 69, 19.7%), diffuse reticuloperitonitis (n = 20, 5.7%), traumatic pericarditis (n = 13, 3.7%), diaphragmatic hernia (n = 6, 1.7%), splenic abscess (n = 3, 0.8%) and absence of complications (n = 9, 2.6%). In conclusion, sharp foreign body syndrome is a common disease in Iraqi buffaloes causing high economic losses and consequently an urgent need for a science based policy is required to control and manage this syndrome.