M. Khaksarian
Department of Physiology, Lorestan University of Medical Sciences, Tehran, Iran
M. Javan
Department of Physiology, School of Medical Sciences, Tarbiat Modarres University, Tehran, Iran
A. Sonboli
Institute of Medicinal Plants, Shaheed Beheshti University, Tehran, Iran
F. Motamedi
Neuroscience Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
ABSTRACT
In this study, Hypericum perforatum L. (HP) aqueous extract was administered intraperitoneally (i.p.) for evaluation of its antinociceptive effect. For assessment of its site of action, HP was filtered and administered both intrathecally (i.t.) and intracerebroventricularly (i.c.v.). Antinociceptive effects of HP extract were evaluated using formalin and tail-flick pain models. Peripheral effects of HP extract were assessed in three doses (200, 400 and 800 mg kg-1, i.p.) and compared with the antinociceptive effect of Sodium Salicylate (SS) as a positive control. Administration of 300 mg kg-1 of SS i.p. had no effect on tail-flick latency, while all doses of extract increased it. In both phases of formalin test, all doses of extract alleviated the animal’s nociception, but SS (300 mg kg-1) produced antinociception only in the second phase of formalin test. In central administration, the HP (1 and 2 mg/rat, i.t.) induced analgesia in the tail-flick and both phases of formalin tests. The i.c.v. administration of HP (2 mg/rat) produced analgesia in both phases of formalin test, but not on tail flick latency. The results showed that peripheral and central administration of HP has antinociceptive effect and its spinal effect seems to be more potent than its cerebral effect.
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How to cite this article
M. Khaksarian, M. Javan, A. Sonboli and F. Motamedi, 2005. The Effects of Peripheral and Central Administration of Hypericum
perforatum L. on Chronic and Acute Pain in Male Rats. Pakistan Journal of Biological Sciences, 8: 949-953.
DOI: 10.3923/pjbs.2005.949.953
URL: https://scialert.net/abstract/?doi=pjbs.2005.949.953
DOI: 10.3923/pjbs.2005.949.953
URL: https://scialert.net/abstract/?doi=pjbs.2005.949.953
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