B. Kazemi
Department of Parasitology, School of Medicine,
Shaheed Beheshti University of Medical Sciences, Tehran, Iran
F. Moazzen
Department of Biotechnology, Isfahan University of Medical Sciences, Isfahan, Iran
A. Abadi
Department of Health and Social Medicine, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
A. Ghadjari
Department of Parasitology, School of Medicine,
Shaheed Beheshti University of Medical Sciences, Tehran, Iran
M. Bandehpour
Cellular and Molecular Biology Research Center,
Shaheed Beheshti University of Medical Sciences, Tehran, Iran
N. Seyed
Cellular and Molecular Biology Research Center,
Shaheed Beheshti University of Medical Sciences, Tehran, Iran
ABSTRACT
The objective of this study was the immunization of balb/C mice by protein fragments of lizard Leishmania promastigote. Mice were divided in 6 case groups and one as control. Each group received a fraction of lizard Leishmania promastigote. Then active pathogenic Leishmania major challenged them separately. We followed up all the case groups (6 groups) till five months after the challenge with Leishmania major together with control group and recorded the lesions diameter. None of the mice manifested detectable wound or nodules, except those at group 6 but the difference compared to control group was not significant according to the Mann-Whitney analytical test.
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How to cite this article
B. Kazemi, F. Moazzen, A. Abadi, A. Ghadjari, M. Bandehpour and N. Seyed, 2004. Immunization of Balb/C Mice by Protein Fragments of Lizard Leishmania promastigote. Pakistan Journal of Biological Sciences, 7: 1699-1702.
DOI: 10.3923/pjbs.2004.1699.1702
URL: https://scialert.net/abstract/?doi=pjbs.2004.1699.1702
DOI: 10.3923/pjbs.2004.1699.1702
URL: https://scialert.net/abstract/?doi=pjbs.2004.1699.1702
REFERENCES
- Kazemi, B., G.H. Tahvildar-Bideroni, S.R. Hashemi Feshareki and E. Javadian, 2004. Isolation a lizard Leishmania promastigote from its natural host in Iran. J. Biol. Sci., 4: 620-623.
CrossRefDirect Link - Kafetzis, D.A., 2003. An overview of paediatric leishmaniasis. J. Postgrad. Med., 49: 31-38.
CrossRefDirect Link - Kazemi, B., F. Moazzen, A. Abadi and A. Ghadjari, 2004. Fractionation of lizard Leishmania promastigote protein Fragment. Pak. J. Biol. Sci., 7: 1703-1705.
CrossRefDirect Link