Bashir M. Jarrar
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ABSTRACT
Four groups of 24 male Wistar albino rats (Rattus norvegicus) were exposed to lead acetate trihydrate (0, 0.5, 1.0, and 2% for 1 to 6 months) in drinking water to investigate the ultrastructural alterations in the renal cortical tissues due to lead intoxication. In comparison with respective control rats, chronic exposure to subtoxic doses of lead had produced adverse alterations mainly in the mitochondria, endoplasmic reticulum, lysosomes and nuclear chromatin with basal membrane infoldings. These changes were mainly seen in the proximal convoluted tubules and increased severely with increasing dose and/or time interval of lead exposure.
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How to cite this article
Bashir M. Jarrar, 2001. Ultrastructural Alterations in Proximal Tubule Cells Induced by Lead . Pakistan Journal of Biological Sciences, 4: 1281-1284.
DOI: 10.3923/pjbs.2001.1281.1284
URL: https://scialert.net/abstract/?doi=pjbs.2001.1281.1284
DOI: 10.3923/pjbs.2001.1281.1284
URL: https://scialert.net/abstract/?doi=pjbs.2001.1281.1284
REFERENCES
- Fowler, B.A., C.A. Kimmel, J.S. Woods, E.E. McConnel and L.D. Grant, 1980. Chronic low-level lead toxicity in the rat: III. An integrated assessment of long-term toxicity with special reference to the kidney. Toxicol. Applied Pharmacol., 56: 59-77.
CrossRefDirect Link - Oskarsson, A., L. Jorhem, J. Sundberg, N.G. Nilsson and L. Albanus, 1992. Lead poisoning in cattle transfer of lead to milk. Sci. Total Environ., 111: 83-94.
PubMedDirect Link - Vyskocil, A., J. Poncl, T. Miloslav, E. Ettlorova, V. Semecky, L. Kasparoval, R. Lauwerys and R. Bernard, 1989. Dose-related proximal tubular dysfunction in male rats chronically exposed to lead. J. Applied Toxicol., 9: 395-399.
CrossRef - Waalkes, M.P., B.A. Diwan, J.M. Ward, D.E. Devor and R.A. Goyer, 1995. Renal tubular tumors and atypical hyperplasia in B6C3F1 mice exposed to lead acetate during gestation and lactation occur with minimal chronic nephropathy. Cancer Res., 55: 5265-5271.
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