Kawshik Kumar Chowdhury
Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
Achinto Saha
Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
Sitesh Chandra Bachar
Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
Joydeb Kumar Kundu
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
ABSTRACT
Successive hexane, ethyl acetate and methanol extracts of Desmodium triflorum DC were subjected to evaluate analgesic and anti-inflammatory activities in animal model. In acetic acid-induced writhing test, the ethyl acetate extract at doses of 150 and 300 mg kg 1 body weight elicited 47.60 and 57.40% inhibition of writhing reflex, respectively but the methanol extract showed 51.48% inhibition at 300 mg kg 1 body weight. Significant elongation of tail flick time was evident both in ethyl acetate and methanol extracts (69.54 and 61.72% elongation, respectively) only at the higher dose. Both the hexane and methanol extracts at a dose of 300 mg kg 1 body weight showed statistically significant (p<0.01) inhibition of rat paw edema by 35.8 and 38.97%, respectively at the third hour after carrageenan injection.
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How to cite this article
Kawshik Kumar Chowdhury, Achinto Saha, Sitesh Chandra Bachar and Joydeb Kumar Kundu, 2005. Analgesic and Anti-inflammatory Activities of Desmodium triflorum DC. Journal of Biological Sciences, 5: 581-583.
DOI: 10.3923/jbs.2005.581.583
URL: https://scialert.net/abstract/?doi=jbs.2005.581.583
DOI: 10.3923/jbs.2005.581.583
URL: https://scialert.net/abstract/?doi=jbs.2005.581.583
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