S. A. Sakr
Zoology Department, Faculty of Science, Menoufia Universiy, Shebin EI-Kom, Egypt
N. I. El-Desouky
Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt
S.M. Hanafy
Zoology Department, Faculty of Science, South Valley University, Aswan, Egypt
ABSTRACT
In this experiment the effect of the synthetic glucocorticoid, methyl prednisolone on the adrenal cortex of albino rat was investigated by applying histological and histochemical techniques. Animals were orally given methyl prednisolone at a dose level of 1.8 mg/kg/body weight dissolved in sterile saline, 3 times/week for 3 weeks. Histological results revealed atrophy of zona fasciculata, thickness of adrenal capsule and hypertrophy of zona reticularis. Total carbohydrate content of the zona glomerulosa, zona fasiculata and zona reticularis cells showed an obvious decrease after treatment which was prominent after 3 weeks. Total protein content showed a marked decrease in zona glomerulosa and zona fasiculata. On the other hand, the cells of zona reticularis appeared with an increase amount of total protein.
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How to cite this article
S. A. Sakr, N. I. El-Desouky and S.M. Hanafy, 2002. Methylprednisolone Induced Histological and Histochemical Changes in the Adrenal Cortex of Rat. Journal of Biological Sciences, 2: 320-324.
DOI: 10.3923/jbs.2002.320.324
URL: https://scialert.net/abstract/?doi=jbs.2002.320.324
DOI: 10.3923/jbs.2002.320.324
URL: https://scialert.net/abstract/?doi=jbs.2002.320.324
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