Magdy S. Aly
Faculty of Science, Cairo University (Beni-Suef Branch), Egypt
Mohamad B. Ashour
Faculty of Science, Cairo University (Beni-Suef Branch), Egypt
Soheir M. El Nahas
Cell Biology Department, National Research Center, Dokki, Egypt
Othman E. Othman
Cell Biology Department, National Research Center, Dokki, Egypt
Hanaa M. Mohamed
Faculty of Science, Cairo University (Beni-Suef Branch), Egypt
ABSTRACT
The present study was conducted to determin the potential genetic damage of occupational exposure to EM field. The studied subjects are engineers and air traffic controllers exposed to radio frequency emitted from different instruments. Lymphocytes of exposed and control individuals were analyzed for structural and numerical chromosomal aberrations, sister chromatid exchanges, mitotic activity and cell kinetics. Cells with structural chromosomal aberrations were significantly increased in both engineers and air traffic controllers (P<0.001). Also, The number of aberrant cells with total numerical aberrations increased significantly in both exposed groups (P<0.001). Numerical aberrations were mainly hypodiploidy. The frequencies of SCEs in engineers and air traffic controllers were slightly increased over the control but this increase was not statistically significant. A decrease in mitotic activity was reported in EM field exposed engineers and air traffic controllers at statistically significant levels of P<0.01 and P<0.001, respectively. Exposure to EM field did not affect the cell kinetics in engineers and air traffic controllers.
PDF References Citation
How to cite this article
Magdy S. Aly, Mohamad B. Ashour, Soheir M. El Nahas, Othman E. Othman and Hanaa M. Mohamed, 2002. Mutagenic Potential of Radio Frequency Electromagnetic Fields. Journal of Biological Sciences, 2: 254-258.
DOI: 10.3923/jbs.2002.254.258
URL: https://scialert.net/abstract/?doi=jbs.2002.254.258
DOI: 10.3923/jbs.2002.254.258
URL: https://scialert.net/abstract/?doi=jbs.2002.254.258
REFERENCES
- Antonopoulos, A., B. Yang, A. Stamm, W.D. Heller and G. Obe, 1995. Cytological effects of 50-Hz electromagnetic fields on human lymphocytes in vitro. Mutat. Res., 346: 151-157.
PubMedDirect Link - Antonopoulos, A., H. Eisenbrandt and G. Obe, 1997. Effects of high-frequency electromagnetic fields on human lymphocytes in vitro. Mutat. Res., 395: 209-214.
PubMedDirect Link - Goto, K., S. Maeda, Y. Kano and T. Sugiyama, 1978. Factors involved in differential Giemsa staining of sister chromatids. Chromosoma, 66: 351-359.
CrossRef - Maes, A., L. Verschave, A. Arroyo, C. DeWagter and L. Vercruyssen, 1993. In vitro cytogenetic effects of 2450 MHZ waves on human peripheral blood lymphocytes. Bioelectromagnetics, 14: 495-501.
PubMedDirect Link - Maes, A., M. Collier, U. VanGorp, S. Vandoninck and L. Verschaeve, 1997. Cytogenetic effects of 935.2 MHz (GSM) microwaves alone and in combination with mitomycin C. Mutation Res., 393: 151-156.
PubMedDirect Link - McCann, J., F. Dietrich, C. Rafferty and A.O. Martin, 1993. A critical reviewof the genotoxic potential of electric and magnetic fields. Mutat. Res., 297: 61-95.
Direct Link - Schneider, E.L. and J. Lewis, 1981. Aging and sister chromatid exchanges. VIII. Effect of the aging environment on sister chromatid induction and cell cycle kinetics in Ehrlich ascites tumor cells, a brief note. Mech. Ageing Dev., 17: 327-330.
CrossRef - Schnorr, T.M., B.A. Grajewski, R.W. Hornung, M.J. Thun and G.M. Egeland et al., 1991. Video display terminals and the risk of spontaneous abortion. New Engl. J. Med., 324: 727-733.
PubMedDirect Link - Skyberg, K., I.L. Hansteen and A.I. Vistnes, 1993. Chromosome aberrations in lymphocytes of high-voltage laboratory cable splicers exposed to electromagnetic fields. Scand. J. Work Environ. Health, 19: 29-34.
PubMedDirect Link - Sobel, E., Z. Davanipour, R. Sulkava, T. Erkinjuntti and J. Wikstrom et al., 1995. Occupations with exposure to electromagnetic fields: A possible risk factor for Alzheimer's disease. Am. J. Epidem., 142: 515-524.
Direct Link - Speers, M.A., J.D. Dobbins and V.S. Miller, 1988. Occupational exposures and brain cancer mortality: A preliminary study of East Texas (USA) residents. Am. J. Ind. Med., 13: 629-638.
CrossRef - Thomas, T.L., P.D. Stolley, A. Stemhagen, E.T.H. Fontham, M.L. Bleecker, P.A. Stewart and R.N. Hoover, 1987. Brain tumor mortality risk among men with electrical and electronics Jobs, a case-control study. J. Nat. Cancer Inst., 79: 233-238.
PubMedDirect Link - Timchenko, O.I. and N.V. Ianchevskaia, 1995. The cytogenetic action of electromagnetic fields in the short-wave range. Lik. Sprava, 7-8: 37-39.
PubMedDirect Link - Tofani, S., A. Ferrara, L. Anglesio and G. Gilli, 1995. Evidence for genotoxic effects of resonant ELF magnetic fields. Bioelectrochem. Bioenergetics, 36: 9-13.
CrossRef - Valjus, J., H. Norppa, H. Jarventaus, M. Sorsa and E. Nykyri et al., 1993. Analysis of chromosomal aberrations, sister chromatid exchanges and micronuclei among power linesmen with long-term exposure to 50-Hz electromagnetic fields. Radiat. Environ. Biophys., 32: 325-336.
PubMedDirect Link - Verkasalo, P., 1996. Magnetic fields and leukemia-risk for adults living close to power lines. Scand. J. Work Environ. Health, 22: 1-56.
PubMedDirect Link - Verschaeve, L. and A. Maes, 1998. Genetic, carcinogenic and teratogenic effects of radiofrequency fields. Mutat. Res., 410: 141-165.
CrossRef - Wertheimer, N. and E. Leeper, 1979. Electrical wiring configurations and childhood cancer. Am. J. Epidemiol., 109: 273-284.
Direct Link - Yao, K.T., 1982. Cytogenetic consequences of microwave irradiation on mammalian cells incubated in vitro. J. Hered., 73: 133-138.
PubMedDirect Link - Zwingelberg, R., G. Obe, M. Rosenthal, M. Mevissen, S. Buntenkotter and W. Loscher, 1993. Exposure of rats to a 50 Hz, 30 mT magnetic field influnces neither the frequencies of sister-chromatid exchanges nor proliferation characteristics of cultured peripheral lymphocytes. Mutat. Res., 302: 39-44.
PubMedDirect Link