Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2013.844.851Hiptage bengalensis Leaves in Alloxan Induced Diabetic Models]]>MaheshwariP. BaburaoB. KumarCh. Pradeep ReddyA. Rama Narsimha 1220131617Diabetes mellitus is a metabolic disorder characterized by
hyperglycemia and its occurrence is increasing fast in most of the countries.
Herbal medicine derived from plant extracts have been utilized increasingly
for the treatment of various disorders like diabetes mellitus. The present study
was designed to evaluate the antidiabetic activity of Methanolic Extract of
Hiptage bengalensis L. Kurz (MEHB) in alloxan induced diabetic rats and
chick model. Alloxan (120 mg kg-1) was used to induce diabetes in
rats and the blood glucose levels were estimated by using commercial kit in
the market. The methanolic extract of Hiptage bengalensis was administered
to diabetic rats as single dose for one day at a dose of 100 and 200 mg kg-1.
The extract produced a significant reduction (p<0.01) of blood glucose levels
at a dose of 100 and 200 mg kg-1 in diabetic rats. It also showed
a beneficial effect on the lipid profile in alloxan induced diabetic rats. These
results showed that methanolic extract of Hiptage bengalensis produced
a dose dependant antihyperglycemic activity in rats.]]>Amudha, P. and P. Shanthi,20114698699Bainton, D., N.E. Miller, C.H. Botton, J.W.G. Yarnell and P.M. Suretman et al.,1992686066Best, C.H. and N.B. Taylor,19891989Bhukya, B., R.N.R. Anreddy and K.M. Gottumukkala,2009Hiptage bengalensis (L.) Kurz.]]>2161164Chattopadhyay, R.R. and M. Bandyopadhyay,2005Azadirachta indica leaf extract on serum lipid profile changes in normal and streptozotocin induced diabetic rats.]]>8101104Chattopadhyay, R.R.,2003Azadirachta indica leaf extract: Part II.]]>89217219Chattopadhyay, R.R., S.K. Sarkar, S. Ganguli, R.N. Banerjee and T.K. Base,1992Vinca rosea Linn. on glucose utilization and glycogen deposition by isolated rat hemidiaphragm.]]>36137138 Danby, R., L. Bluff, T.P. Deheny and W.R. Gibson,198247159169Dash, G.K., S.K. Bal, M.M. Annapurna and P. Suresh,2008Hemidesmus indicus R. Br. roots.]]>4221225Heath, D.A., J.F. Amos and S.C. Miller,20092009Erah, P.O., G.E. Osuide and E.K.I. Omogbai,1996Solenostemon monostachys leaves.]]>102127Fernandes, N.P.C., C.V. Lagishetty, V.S. Panda and S.R. Naik,20072007Halliwell, B. and J.M. Gutteridge,19852nd Edn.,Harborne, J.B.,19983rd Edn.,Pages: 302Pages: 302Jeong, H.G., H.J. You, S.J. Park, A.R. Moon, Y.C. Chung, S.K. Kang and H.K. Chun,200246221227Kesavulu, M.M., R. Giri, R.B. Kameswara and C. Apparao,200026387392Kokate, C.K.,1994Krishnakumar, K., K.T. Augusti and P.L. Vijayammal,2000Salacia oblonga Wall. root bark in streptozotocin diabetic rats.]]>286567Nofer, J.R., B. Kehrel, M. Fobker, B. Levkau, G. Assmann and A. von Eckardstein,2002161116OECD,20002000Saravanan, G. and L. Pari,20035156162Parrotta, J.A.,2001Pages: 917Pages: 917Pushparaj, P., C.H. Tan and B.K.H. Tan,2000Averrhoa bilimbi leaf extract on blood glucose and lipids in streptozotocin-diabetic rats.]]>726976Luo, Q., Y. Cai, J. Yan, M. Sun and H. Corke,2004Lycium barbarum.]]>76137149Ragavan, B. and S. Krishnakumari,20066124130Maiti, R., U.K. Das and D. Ghosh,2005Tamarindus indica.]]>2811721176Saravanan, R. and L. Pari,20052005Ravi, K., S. Rajasekaran and S. Subramanian,20054314331439Sharma, S.B., A. Nasir, K.M. Prabhu, P.S. Murthy and G. Dev,2003Eugenia jambolana in alloxan-induced diabetic rabbits.]]>85201206Siddharth, N.S.,200131111Suba, V., T. Murugesan, R.B. Rao, L. Ghosh, M. Pal, S.C. Mandal and B.P. Saha,2004Barleria lupulina extract in rats.]]>7514Temme, E.H., H.P.G. Van, E.G. Schouten and H. Kesteloot,200257111115Tiwari, A.K. and J. Madhusudana Rao,2002833037Yadav, U.C. S., K. Moorthy and N.Z. Baquer,2005Momordica charantia fruit extract prevents alterations in lipid profile and lipogenic enzymes an alloxan diabetic rats.]]>268111120Bobbarala, V., P.K. Katikala, K.C. Naidu, S. Penumajji,2009Aspergillus niger F2723.]]>28790Vats, V., S.P. Yadav and J.K. Grover,2004Ocimum sanctum leaves partially attenuates streptozotocin-induced alterations in glycogen content and carbohydrate metabolism in rats.]]>90155160Sharma, V.K., S. Kumar, H.J. Patel and S. Hugar,2010Ficus glomerata in alloxan induced diabetic rats.]]>11822Walaas, E. and O. Walaas,1952195367373Yashiyama, Y., T. Sugiyama and M. Kanke,20052005Yoshiyama, Y., T. Sugiyama and M. Kanke,20052819861988Lenzen, S.,200851216226